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Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding

The structure-thermodynamics correlation analysis was performed for a series of fluorine- and chlorine-substituted benzenesulfonamide inhibitors binding to several human carbonic anhydrase (CA) isoforms. The total of 24 crystal structures of 16 inhibitors bound to isoforms CA I, CA II, CA XII, and C...

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Detalles Bibliográficos
Autores principales:	Smirnov, Alexey, Zubrienė, Asta, Manakova, Elena, Gražulis, Saulius, Matulis, Daumantas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2018
Materias:	Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831161/ https://www.ncbi.nlm.nih.gov/pubmed/29503769 http://dx.doi.org/10.7717/peerj.4412

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