Cargando…

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

BACKGROUND: Besides the two main classical features of amyloid beta aggregation and tau-containing neurofibrillary tangle deposition, neuroinflammation plays an important yet unclear role in the pathophysiology of Alzheimer’s disease (AD). Microglia are believed to be key mediators of neuroinflammat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sosna, Justyna, Philipp, Stephan, Albay, Ricardo, Reyes-Ruiz, Jorge Mauricio, Baglietto-Vargas, David, LaFerla, Frank M., Glabe, Charles G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831225/ https://www.ncbi.nlm.nih.gov/pubmed/29490706 http://dx.doi.org/10.1186/s13024-018-0244-x

Ejemplares similares

Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells
por: Okojie, Akhabue K., et al.
Publicado: (2023)

Depletion of microglia with PLX3397 attenuates MK-801-induced hyperactivity associated with regulating inflammation-related genes in the brain
por: Ni, Rong-Jun, et al.
Publicado: (2023)

Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice
por: Son, Yeonghoon, et al.
Publicado: (2020)

Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors
por: Wesolowski, Robert, et al.
Publicado: (2019)

Age-Related Intraneuronal Aggregation of Amyloid-β in Endosomes, Mitochondria, Autophagosomes, and Lysosomes
por: Brewer, Gregory J., et al.
Publicado: (2020)

A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel
por: Piawah, Sorbarikor, et al.
Publicado: (2019)

Novel CSF1R-positive tenosynovial giant cell tumor cell lines and their pexidartinib (PLX3397) and sotuletinib (BLZ945)-induced apoptosis
por: Thongchot, Suyanee, et al.
Publicado: (2022)

Pexidartinib (PLX3397) through restoring hippocampal synaptic plasticity ameliorates social isolation-induced mood disorders
por: Wang, Laifa, et al.
Publicado: (2022)

Tenosynovial giant cell tumor: case report of a patient effectively treated with pexidartinib (PLX3397) and review of the literature
por: Giustini, Nicholas, et al.
Publicado: (2018)

A Phase I Study of Binimetinib (MEK162) Combined with Pexidartinib (PLX3397) in Patients with Advanced Gastrointestinal Stromal Tumor
por: Rosenbaum, Evan, et al.
Publicado: (2019)

Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat
por: Wyatt-Johnson, Season K., et al.
Publicado: (2021)

Anti-Anaplastic Thyroid Cancer (ATC) Effects and Mechanisms of PLX3397 (Pexidartinib), a Multi-Targeted Tyrosine Kinase Inhibitor (TKI)
por: Luo, Jingtao, et al.
Publicado: (2022)

Significant Sex Differences in the Efficacy of the CSF1R Inhibitor-PLX5622 on Rat Brain Microglia Elimination
por: Sharon, Aviv, et al.
Publicado: (2022)

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
por: Youmans, Katherine L, et al.
Publicado: (2012)

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
por: Kayed, Rakez, et al.
Publicado: (2007)

Is there a sodium effect in fibrillar amyloid-β oligomers?
por: Horn, Anselm HC, et al.
Publicado: (2014)

3397 Genetic variants in gestational diabetes mellitus
por: Kothiyal, Prachi, et al.
Publicado: (2019)

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
por: Rasool, Suhail, et al.
Publicado: (2012)

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ(42) accumulation and Caspase-3 activation
por: Eimer, William A, et al.
Publicado: (2013)

Putting PLX5622 into perspective: microglia in central nervous system viral infection
por: Spiteri, Alanna G., et al.
Publicado: (2022)

Stability of single and double layer fibrillar amyloid-β oligomers
por: Kahler, Anna, et al.
Publicado: (2013)

New Alzheimer’s disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers
por: Ochiishi, Tomoyo, et al.
Publicado: (2019)

Accumulation of Intraneuronal β-Amyloid 42 Peptides Is Associated with Early Changes in Microtubule-Associated Protein 2 in Neurites and Synapses
por: Takahashi, Reisuke H., et al.
Publicado: (2013)

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease
por: Forner, Stefania, et al.
Publicado: (2021)

Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation
por: Kulic, L, et al.
Publicado: (2012)

Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer’s disease
por: Martini, Alessandra C., et al.
Publicado: (2020)

Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-β Accumulation and Plaque Deposition in a Transgenic Alzheimer’s Disease Mouse Model
por: Pontrello, Crystal G., et al.
Publicado: (2022)

Hippocampal Adaptive Response Following Extensive Neuronal Loss in an Inducible Transgenic Mouse Model
por: Myczek, Kristoffer, et al.
Publicado: (2014)

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers
por: Kayed, Rakez, et al.
Publicado: (2010)

Reply to Green and Hume: Nonmicroglia peripheral immune effects of short-term CSF1R inhibition with PLX5622
por: Lei, Fengyang, et al.
Publicado: (2021)

Selective Aptamer‐Based Control of Intraneuronal Signaling
por: Lennarz, Sabine, et al.
Publicado: (2015)

Terminal field volume of the glossopharyngeal nerve in adult rats reverts to prepruning size following microglia depletion with PLX5622
por: Riquier, Andrew J., et al.
Publicado: (2022)

CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice
por: Ali, Seemaab, et al.
Publicado: (2020)

Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis
por: Sadleir, Katherine R., et al.
Publicado: (2022)

Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia
por: Bao, Jintao, et al.
Publicado: (2016)

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes
por: Scheiblich, Hannah, et al.
Publicado: (2021)

Conformational Stability of Fibrillar Amyloid-Beta Oligomers via Protofilament Pair Formation – A Systematic Computational Study
por: Kahler, Anna, et al.
Publicado: (2013)

Synapses, Synaptic Activity and Intraneuronal Aβ in Alzheimer's Disease
por: Tampellini, Davide, et al.
Publicado: (2010)

Intraneuronal tau aggregation induces the integrated stress response in astrocytes
por: Batenburg, Kevin L, et al.
Publicado: (2022)

Chemogenetic emulation of intraneuronal oxidative stress affects synaptic plasticity
por: Kalinichenko, Andrei L., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qs9iiqi2lin7f2np3h0aefn0uh