Genetic ablation of dynactin p150(Glued) in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice

BACKGROUND: Dynactin p150(Glued), the largest subunit of the dynactin macromolecular complex, binds to both microtubules and tubulin dimers through the N-terminal cytoskeleton-associated protein and glycine-rich (CAP-Gly) and basic domains, and serves as an anti-catastrophe factor in stabilizing mic...

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Detalles Bibliográficos
Autores principales: Yu, Jia, Lai, Chen, Shim, Hoon, Xie, Chengsong, Sun, Lixin, Long, Cai-Xia, Ding, Jinhui, Li, Yan, Cai, Huaibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831668/
https://www.ncbi.nlm.nih.gov/pubmed/29490687
http://dx.doi.org/10.1186/s13024-018-0242-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831668/
https://www.ncbi.nlm.nih.gov/pubmed/29490687
http://dx.doi.org/10.1186/s13024-018-0242-z

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