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Genetic ablation of dynactin p150(Glued) in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice

BACKGROUND: Dynactin p150(Glued), the largest subunit of the dynactin macromolecular complex, binds to both microtubules and tubulin dimers through the N-terminal cytoskeleton-associated protein and glycine-rich (CAP-Gly) and basic domains, and serves as an anti-catastrophe factor in stabilizing mic...

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Detalles Bibliográficos
Autores principales:	Yu, Jia, Lai, Chen, Shim, Hoon, Xie, Chengsong, Sun, Lixin, Long, Cai-Xia, Ding, Jinhui, Li, Yan, Cai, Huaibin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831668/ https://www.ncbi.nlm.nih.gov/pubmed/29490687 http://dx.doi.org/10.1186/s13024-018-0242-z

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