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Sonic Hedgehog—‘Jack-of-All-Trades’ in Neural Circuit Formation

As reflected by the term morphogen, molecules such as Shh and Wnts were identified based on their role in early development when they instruct precursor cells to adopt a specific cell fate. Only much later were they implicated in neural circuit formation. Both in vitro and in vivo studies indicated...

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Detalles Bibliográficos
Autores principales: Zuñiga, Nikole R., Stoeckli, Esther T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831768/
https://www.ncbi.nlm.nih.gov/pubmed/29615560
http://dx.doi.org/10.3390/jdb5010002
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author Zuñiga, Nikole R.
Stoeckli, Esther T.
author_facet Zuñiga, Nikole R.
Stoeckli, Esther T.
author_sort Zuñiga, Nikole R.
collection PubMed
description As reflected by the term morphogen, molecules such as Shh and Wnts were identified based on their role in early development when they instruct precursor cells to adopt a specific cell fate. Only much later were they implicated in neural circuit formation. Both in vitro and in vivo studies indicated that morphogens direct axons during their navigation through the developing nervous system. Today, the best understood role of Shh and Wnt in axon guidance is their effect on commissural axons in the spinal cord. Shh was shown to affect commissural axons both directly and indirectly via its effect on Wnt signaling. In fact, throughout neural circuit formation there is cross-talk and collaboration of Shh and Wnt signaling. Thus, although the focus of this review is on the role of Shh in neural circuit formation, a separation from Wnt signaling is not possible.
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spelling pubmed-58317682018-03-30 Sonic Hedgehog—‘Jack-of-All-Trades’ in Neural Circuit Formation Zuñiga, Nikole R. Stoeckli, Esther T. J Dev Biol Review As reflected by the term morphogen, molecules such as Shh and Wnts were identified based on their role in early development when they instruct precursor cells to adopt a specific cell fate. Only much later were they implicated in neural circuit formation. Both in vitro and in vivo studies indicated that morphogens direct axons during their navigation through the developing nervous system. Today, the best understood role of Shh and Wnt in axon guidance is their effect on commissural axons in the spinal cord. Shh was shown to affect commissural axons both directly and indirectly via its effect on Wnt signaling. In fact, throughout neural circuit formation there is cross-talk and collaboration of Shh and Wnt signaling. Thus, although the focus of this review is on the role of Shh in neural circuit formation, a separation from Wnt signaling is not possible. MDPI 2017-02-08 /pmc/articles/PMC5831768/ /pubmed/29615560 http://dx.doi.org/10.3390/jdb5010002 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zuñiga, Nikole R.
Stoeckli, Esther T.
Sonic Hedgehog—‘Jack-of-All-Trades’ in Neural Circuit Formation
title Sonic Hedgehog—‘Jack-of-All-Trades’ in Neural Circuit Formation
title_full Sonic Hedgehog—‘Jack-of-All-Trades’ in Neural Circuit Formation
title_fullStr Sonic Hedgehog—‘Jack-of-All-Trades’ in Neural Circuit Formation
title_full_unstemmed Sonic Hedgehog—‘Jack-of-All-Trades’ in Neural Circuit Formation
title_short Sonic Hedgehog—‘Jack-of-All-Trades’ in Neural Circuit Formation
title_sort sonic hedgehog—‘jack-of-all-trades’ in neural circuit formation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831768/
https://www.ncbi.nlm.nih.gov/pubmed/29615560
http://dx.doi.org/10.3390/jdb5010002
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