Drosophila as a Model to Study the Link between Metabolism and Cancer

Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these changes contribute to disease progression and may suggest n...

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Detalles Bibliográficos
Autores principales: Herranz, Héctor, Cohen, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831792/
https://www.ncbi.nlm.nih.gov/pubmed/29615570
http://dx.doi.org/10.3390/jdb5040015
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author Herranz, Héctor
Cohen, Stephen M.
author_facet Herranz, Héctor
Cohen, Stephen M.
author_sort Herranz, Héctor
collection PubMed
description Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these changes contribute to disease progression and may suggest new approaches to therapy. Drosophila melanogaster is emerging as a valuable model to study multiple aspects of tumor formation and malignant transformation. In this review, we discuss the use of Drosophila as model to study how changes in cellular metabolism, as well as metabolic disease, contribute to cancer.
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spelling pubmed-58317922018-03-30 Drosophila as a Model to Study the Link between Metabolism and Cancer Herranz, Héctor Cohen, Stephen M. J Dev Biol Review Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these changes contribute to disease progression and may suggest new approaches to therapy. Drosophila melanogaster is emerging as a valuable model to study multiple aspects of tumor formation and malignant transformation. In this review, we discuss the use of Drosophila as model to study how changes in cellular metabolism, as well as metabolic disease, contribute to cancer. MDPI 2017-12-01 /pmc/articles/PMC5831792/ /pubmed/29615570 http://dx.doi.org/10.3390/jdb5040015 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Herranz, Héctor
Cohen, Stephen M.
Drosophila as a Model to Study the Link between Metabolism and Cancer
title Drosophila as a Model to Study the Link between Metabolism and Cancer
title_full Drosophila as a Model to Study the Link between Metabolism and Cancer
title_fullStr Drosophila as a Model to Study the Link between Metabolism and Cancer
title_full_unstemmed Drosophila as a Model to Study the Link between Metabolism and Cancer
title_short Drosophila as a Model to Study the Link between Metabolism and Cancer
title_sort drosophila as a model to study the link between metabolism and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831792/
https://www.ncbi.nlm.nih.gov/pubmed/29615570
http://dx.doi.org/10.3390/jdb5040015
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