Pharmacological characterisation of CR6086, a potent prostaglandin E(2) receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug

BACKGROUND: Prostaglandin E(2) (PGE(2)) acts via its EP4 receptor as a cytokine amplifier (e.g., interleukin [IL]-6) and induces the differentiation and expansion of inflammatory T-helper (Th) lymphocytes. These mechanisms play a key role in the onset and progression of rheumatoid arthritis (RA). We...

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Detalles Bibliográficos
Autores principales: Caselli, Gianfranco, Bonazzi, Albino, Lanza, Marco, Ferrari, Flora, Maggioni, Daniele, Ferioli, Cristian, Giambelli, Roberto, Comi, Eleonora, Zerbi, Silvia, Perrella, Marco, Letari, Ornella, Di Luccio, Elena, Colovic, Milena, Persiani, Stefano, Zanelli, Tiziano, Mennuni, Laura, Piepoli, Tiziana, Rovati, Lucio Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831858/
https://www.ncbi.nlm.nih.gov/pubmed/29490676
http://dx.doi.org/10.1186/s13075-018-1537-8

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