Cargando…

Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer’s disease, whereas amyloid deposition does not

BACKGROUND: The underlying mechanism of brain glucose hypometabolism, an invariant neurodegenerative feature that tightly correlates with cognitive impairment and disease progression of Alzheimer’s disease (AD), remains elusive. METHODS: Positron emission tomography with 2-[(18)F]fluoro-2-deoxy-d-gl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sang, Shaoming, Pan, Xiaoli, Chen, Zhichun, Zeng, Fan, Pan, Shumei, Liu, Huimin, Jin, Lirong, Fei, Guoqiang, Wang, Changpeng, Ren, Shuhua, Jiao, Fangyang, Bao, Weiqi, Zhou, Weiyan, Guan, Yihui, Zhang, Yiqiu, Shi, Hongcheng, Wang, Yanjiang, Yu, Xiang, Wang, Yun, Zhong, Chunjiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831864/ https://www.ncbi.nlm.nih.gov/pubmed/29490669 http://dx.doi.org/10.1186/s13195-018-0354-2

Ejemplares similares

Diagnostic value of blood thiamine metabolites in Alzheimer’s disease examined by (11)C-PiB PET scanning
por: Chen, Zhichun, et al.
Publicado: (2017)

Measurement of Blood Thiamine Metabolites for Alzheimer's Disease Diagnosis
por: Pan, Xiaoli, et al.
Publicado: (2015)

Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease
por: Pan, Xiaoli, et al.
Publicado: (2017)

A novel PET tracer (18)F-deoxy-thiamine: synthesis, metabolic kinetics, and evaluation on cerebral thiamine metabolism status
por: Wang, Changpeng, et al.
Publicado: (2020)

Potent Radical-Scavenging Activities of Thiamin and Thiamin Diphosphate
por: Okai, Yasuji, et al.
Publicado: (2007)

The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeasts
por: Kowalska, Ewa, et al.
Publicado: (2008)

Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues
por: Chan, Alex H. Y., et al.
Publicado: (2023)

Thiamine Diphosphate in Whole Blood, Thiamine and Thiamine Monophosphate in Breast-Milk in a Refugee Population
por: Stuetz, Wolfgang, et al.
Publicado: (2012)

Thiamine deficiency contributes to synapse and neural circuit defects
por: Yu, Qiujian, et al.
Publicado: (2018)

Thiamine metabolism is critical for regulating correlated growth of dendrite arbors and neuronal somata
por: Liu, Huimin, et al.
Publicado: (2017)

Decreased Function of Delayed Recall in Non-demented Elderly Subjects With Apolipoprotein E ε4 Allele
por: Wang, Lijun, et al.
Publicado: (2019)

Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women
por: McCann, Adrian, et al.
Publicado: (2017)

Association Between Blood Biochemical Factors Contributing to Cognitive Decline and B Vitamins in Patients With Alzheimer's Disease
por: Qian, Ting, et al.
Publicado: (2022)

Biochemical and Structural Insights into a Thiamine Diphosphate-Dependent α-Ketoglutarate Decarboxylase from Cyanobacterium Microcystis aeruginosa NIES-843
por: Li, Zhi-Min, et al.
Publicado: (2023)

A standard numbering scheme for thiamine diphosphate-dependent decarboxylases
por: Vogel, Constantin, et al.
Publicado: (2012)

Iron Deposition Leads to Neuronal α-Synuclein Pathology by Inducing Autophagy Dysfunction
por: Wan, Wenbin, et al.
Publicado: (2017)

Thiamine diphosphate adenylyl transferase from E. coli: functional characterization of the enzyme synthesizing adenosine thiamine triphosphate
por: Makarchikov, Alexander F, et al.
Publicado: (2007)

The coenzyme thiamine diphosphate displays a daily rhythm in the Arabidopsis nucleus
por: Noordally, Zeenat B., et al.
Publicado: (2020)

Mitochondria from cultured cells derived from normal and thiamine-responsive megaloblastic anemia individuals efficiently import thiamine diphosphate
por: Song, Qilin, et al.
Publicado: (2002)

Comparison of Thiamin Diphosphate High-Performance Liquid Chromatography and Erythrocyte Transketolase Assays for Evaluating Thiamin Status in Malaria Patients without Beriberi
por: Taylor, Andrew J., et al.
Publicado: (2020)

The Thiamine diphosphate dependent Enzyme Engineering Database: A tool for the systematic analysis of sequence and structure relations
por: Widmann, Michael, et al.
Publicado: (2010)

Assessing the Thiamine Diphosphate Dependent Pyruvate Dehydrogenase E1 Subunit for Carboligation Reactions with Aliphatic Ketoacids
por: Marsden, Stefan R., et al.
Publicado: (2020)

Identification of biomarkers differentiating Alzheimer’s disease from other neurodegenerative diseases by integrated bioinformatic analysis and machine-learning strategies
por: Jin, Boru, et al.
Publicado: (2023)

Acute Respiratory Failure Is the Initial Manifestation in the Adult-Onset A3243G tRNALeu mtDNA Mutation: A Case Report and the Literature Review
por: Pan, Xiaoli, et al.
Publicado: (2019)

Computational characterization of enzyme-bound thiamin diphosphate reveals a surprisingly stable tricyclic state: implications for catalysis
por: Planas, Ferran, et al.
Publicado: (2019)

Identification of diagnostic biomarkers in Alzheimer’s disease by integrated bioinformatic analysis and machine learning strategies
por: Jin, Boru, et al.
Publicado: (2023)

Downregulation of Transketolase Activity Is Related to Inhibition of Hippocampal Progenitor Cell Proliferation Induced by Thiamine Deficiency
por: Zhao, Yanling, et al.
Publicado: (2014)

Physiological Roles of β-amyloid in Regulating Synaptic Function: Implications for AD Pathophysiology
por: Cai, Wenwen, et al.
Publicado: (2022)

Combined Visualization of Nigrosome-1 and Neuromelanin in the Substantia Nigra Using 3T MRI for the Differential Diagnosis of Essential Tremor and de novo Parkinson's Disease
por: Jin, Lirong, et al.
Publicado: (2019)

Five-Minute Cognitive Test as A New Quick Screening of Cognitive Impairment in The Elderly
por: Zhang, Jie, et al.
Publicado: (2019)

Hypometabolism as a therapeutic target in Alzheimer's disease
por: Costantini, Lauren C, et al.
Publicado: (2008)

Poisson Noise Obscures Hypometabolic Lesions in PET
por: Kerr, Wesley T., et al.
Publicado: (2012)

Mirror writing and cortical hypometabolism in Parkinson’s disease
por: Shinohara, Mayumi, et al.
Publicado: (2022)

Patterns of hypometabolism in frontal lobe epilepsy originating in different frontal regions
por: Zhao, Zexian, et al.
Publicado: (2022)

The Significance of Insular Hypometabolism in Temporal Lobe Epilepsy in Children
por: Hur, Ji Ae, et al.
Publicado: (2013)

Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease
por: Scheltens, Nienke M.E., et al.
Publicado: (2018)

Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease
por: Ng, Kok Pin, et al.
Publicado: (2017)

Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice
por: Scott, Karen A., et al.
Publicado: (2023)

Hypometabolism, Alzheimer’s Disease, and Possible Therapeutic Targets: An Overview
por: Raut, Snehal, et al.
Publicado: (2023)

Illumina Sequencing Approach to Characterize Thiamine Metabolism Related Bacteria and the Impacts of Thiamine Supplementation on Ruminal Microbiota in Dairy Cows Fed High-Grain Diets
por: Pan, Xiaohua, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_c324v8cv6ioe7aqf2a08n18gr6