Current Perspectives in Set7 Mediated Stem Cell Differentiation

Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimenta...

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Detalles Bibliográficos
Autores principales: Karimnia, Nazanin, Rafehi, Haloom, Tuano, Natasha K., Ziemann, Mark, K.N., Harikrishnan, Okabe, Jun, El-Osta, Assam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831927/
https://www.ncbi.nlm.nih.gov/pubmed/29657272
http://dx.doi.org/10.3390/ncrna2040014
Descripción
Sumario:Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity.

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