Current Perspectives in Set7 Mediated Stem Cell Differentiation

Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimenta...

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Autores principales: Karimnia, Nazanin, Rafehi, Haloom, Tuano, Natasha K., Ziemann, Mark, K.N., Harikrishnan, Okabe, Jun, El-Osta, Assam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831927/
https://www.ncbi.nlm.nih.gov/pubmed/29657272
http://dx.doi.org/10.3390/ncrna2040014
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author Karimnia, Nazanin
Rafehi, Haloom
Tuano, Natasha K.
Ziemann, Mark
K.N., Harikrishnan
Okabe, Jun
El-Osta, Assam
author_facet Karimnia, Nazanin
Rafehi, Haloom
Tuano, Natasha K.
Ziemann, Mark
K.N., Harikrishnan
Okabe, Jun
El-Osta, Assam
author_sort Karimnia, Nazanin
collection PubMed
description Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity.
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spelling pubmed-58319272018-04-12 Current Perspectives in Set7 Mediated Stem Cell Differentiation Karimnia, Nazanin Rafehi, Haloom Tuano, Natasha K. Ziemann, Mark K.N., Harikrishnan Okabe, Jun El-Osta, Assam Noncoding RNA Communication Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity. MDPI 2016-12-04 /pmc/articles/PMC5831927/ /pubmed/29657272 http://dx.doi.org/10.3390/ncrna2040014 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Karimnia, Nazanin
Rafehi, Haloom
Tuano, Natasha K.
Ziemann, Mark
K.N., Harikrishnan
Okabe, Jun
El-Osta, Assam
Current Perspectives in Set7 Mediated Stem Cell Differentiation
title Current Perspectives in Set7 Mediated Stem Cell Differentiation
title_full Current Perspectives in Set7 Mediated Stem Cell Differentiation
title_fullStr Current Perspectives in Set7 Mediated Stem Cell Differentiation
title_full_unstemmed Current Perspectives in Set7 Mediated Stem Cell Differentiation
title_short Current Perspectives in Set7 Mediated Stem Cell Differentiation
title_sort current perspectives in set7 mediated stem cell differentiation
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831927/
https://www.ncbi.nlm.nih.gov/pubmed/29657272
http://dx.doi.org/10.3390/ncrna2040014
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