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Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis

Cytomegalovirus (CMV) retinitis is one of the rare but debilitating presentations of the CMV infection in children with leukemia. Herein, we report a 12-year-old boy with acute myeloid leukemia complicated by rapid progressive visual loss during relapse of leukemia. The definite diagnosis of CMV ret...

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Autores principales: Amanati, Ali, Shakibazad, Nader, Pourabbas, Bahman, Nowroozzadeh, Mohammad Hossein, Zareifar, Soheila, Zekavat, Omid Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831968/
https://www.ncbi.nlm.nih.gov/pubmed/29560000
http://dx.doi.org/10.1155/2018/2840707
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author Amanati, Ali
Shakibazad, Nader
Pourabbas, Bahman
Nowroozzadeh, Mohammad Hossein
Zareifar, Soheila
Zekavat, Omid Reza
author_facet Amanati, Ali
Shakibazad, Nader
Pourabbas, Bahman
Nowroozzadeh, Mohammad Hossein
Zareifar, Soheila
Zekavat, Omid Reza
author_sort Amanati, Ali
collection PubMed
description Cytomegalovirus (CMV) retinitis is one of the rare but debilitating presentations of the CMV infection in children with leukemia. Herein, we report a 12-year-old boy with acute myeloid leukemia complicated by rapid progressive visual loss during relapse of leukemia. The definite diagnosis of CMV retinitis was made after vitreous aspiration. Despite prompt treatment and ophthalmologic intervention, he died because of AML relapse. Viral infections, especially cytomegalovirus infection, may present with vague clinical pictures during any time of chemotherapy, which may not be easily distinguishable from bacterial or fungal retinitis and also chemotherapy-induced retinopathies. Clinician should consider CMV retinitis in seropositive patients especially those without detectable viremia.
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spelling pubmed-58319682018-03-20 Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis Amanati, Ali Shakibazad, Nader Pourabbas, Bahman Nowroozzadeh, Mohammad Hossein Zareifar, Soheila Zekavat, Omid Reza Case Rep Med Case Report Cytomegalovirus (CMV) retinitis is one of the rare but debilitating presentations of the CMV infection in children with leukemia. Herein, we report a 12-year-old boy with acute myeloid leukemia complicated by rapid progressive visual loss during relapse of leukemia. The definite diagnosis of CMV retinitis was made after vitreous aspiration. Despite prompt treatment and ophthalmologic intervention, he died because of AML relapse. Viral infections, especially cytomegalovirus infection, may present with vague clinical pictures during any time of chemotherapy, which may not be easily distinguishable from bacterial or fungal retinitis and also chemotherapy-induced retinopathies. Clinician should consider CMV retinitis in seropositive patients especially those without detectable viremia. Hindawi 2018-01-31 /pmc/articles/PMC5831968/ /pubmed/29560000 http://dx.doi.org/10.1155/2018/2840707 Text en Copyright © 2018 Ali Amanati et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Amanati, Ali
Shakibazad, Nader
Pourabbas, Bahman
Nowroozzadeh, Mohammad Hossein
Zareifar, Soheila
Zekavat, Omid Reza
Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis
title Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis
title_full Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis
title_fullStr Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis
title_full_unstemmed Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis
title_short Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis
title_sort acute progressive visual loss in a case of acute myeloid leukemia: challenges in the utility of molecular tests in early diagnose of cytomegalovirus retinitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831968/
https://www.ncbi.nlm.nih.gov/pubmed/29560000
http://dx.doi.org/10.1155/2018/2840707
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