Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer

Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhome, Rahul, Del Vecchio, Filippo, Lee, Gui-Han, Bullock, Marc D., Primrose, John N., Sayan, A. Emre, Mirnezami, Alex H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ireland 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831981/
https://www.ncbi.nlm.nih.gov/pubmed/29425686
http://dx.doi.org/10.1016/j.canlet.2018.02.002
Descripción
Sumario:Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified functional roles for exomiRs in influencing many hallmarks of cancer. Mechanisms underpinning their actions, such as exomiR receptors (“miRceptors”), are now becoming apparent. Even more exciting is the fact that exomiRs are highly suitable candidates for use as non-invasive biomarkers in an era of personalized cancer medicine.

Ejemplares similares