Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer

Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified...

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Detalles Bibliográficos
Autores principales: Bhome, Rahul, Del Vecchio, Filippo, Lee, Gui-Han, Bullock, Marc D., Primrose, John N., Sayan, A. Emre, Mirnezami, Alex H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ireland 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831981/
https://www.ncbi.nlm.nih.gov/pubmed/29425686
http://dx.doi.org/10.1016/j.canlet.2018.02.002
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author Bhome, Rahul
Del Vecchio, Filippo
Lee, Gui-Han
Bullock, Marc D.
Primrose, John N.
Sayan, A. Emre
Mirnezami, Alex H.
author_facet Bhome, Rahul
Del Vecchio, Filippo
Lee, Gui-Han
Bullock, Marc D.
Primrose, John N.
Sayan, A. Emre
Mirnezami, Alex H.
author_sort Bhome, Rahul
collection PubMed
description Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified functional roles for exomiRs in influencing many hallmarks of cancer. Mechanisms underpinning their actions, such as exomiR receptors (“miRceptors”), are now becoming apparent. Even more exciting is the fact that exomiRs are highly suitable candidates for use as non-invasive biomarkers in an era of personalized cancer medicine.
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spelling pubmed-58319812018-04-28 Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer Bhome, Rahul Del Vecchio, Filippo Lee, Gui-Han Bullock, Marc D. Primrose, John N. Sayan, A. Emre Mirnezami, Alex H. Cancer Lett Article Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified functional roles for exomiRs in influencing many hallmarks of cancer. Mechanisms underpinning their actions, such as exomiR receptors (“miRceptors”), are now becoming apparent. Even more exciting is the fact that exomiRs are highly suitable candidates for use as non-invasive biomarkers in an era of personalized cancer medicine. Elsevier Science Ireland 2018-04-28 /pmc/articles/PMC5831981/ /pubmed/29425686 http://dx.doi.org/10.1016/j.canlet.2018.02.002 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bhome, Rahul
Del Vecchio, Filippo
Lee, Gui-Han
Bullock, Marc D.
Primrose, John N.
Sayan, A. Emre
Mirnezami, Alex H.
Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer
title Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer
title_full Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer
title_fullStr Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer
title_full_unstemmed Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer
title_short Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer
title_sort exosomal micrornas (exomirs): small molecules with a big role in cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831981/
https://www.ncbi.nlm.nih.gov/pubmed/29425686
http://dx.doi.org/10.1016/j.canlet.2018.02.002
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