Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy

Human beta defensin 2 (HBD2) is an endogenous mucosal antimicrobial peptide (AMP) upregulated during infection and inflammation. HBD2 is encoded by the DEFB4 gene, which exhibits extensive copy number variation. Previous studies have demonstrated a relationship between HBD copy number and serum HBD2...

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Autores principales: James, Catherine P., Bajaj-Elliott, Mona, Abujaber, Razan, Forya, Frida, Klein, Nigel, David, Anna L., Hollox, Edward J., Peebles, Donald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831986/
https://www.ncbi.nlm.nih.gov/pubmed/29367706
http://dx.doi.org/10.1038/s41431-017-0061-7
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author James, Catherine P.
Bajaj-Elliott, Mona
Abujaber, Razan
Forya, Frida
Klein, Nigel
David, Anna L.
Hollox, Edward J.
Peebles, Donald M.
author_facet James, Catherine P.
Bajaj-Elliott, Mona
Abujaber, Razan
Forya, Frida
Klein, Nigel
David, Anna L.
Hollox, Edward J.
Peebles, Donald M.
author_sort James, Catherine P.
collection PubMed
description Human beta defensin 2 (HBD2) is an endogenous mucosal antimicrobial peptide (AMP) upregulated during infection and inflammation. HBD2 is encoded by the DEFB4 gene, which exhibits extensive copy number variation. Previous studies have demonstrated a relationship between HBD copy number and serum HBD2 protein levels; however, our current understanding of the influence of copy number on mucosal AMP function remains limited. This study explores the relationship between HBD copy number, cervicovaginal HBD2 protein levels and antimicrobial activity in 203 women with risk factors for preterm birth. We provide evidence that suggests HBD copy number modulates cervical antimicrobial immunity.
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spelling pubmed-58319862018-06-20 Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy James, Catherine P. Bajaj-Elliott, Mona Abujaber, Razan Forya, Frida Klein, Nigel David, Anna L. Hollox, Edward J. Peebles, Donald M. Eur J Hum Genet Brief Communication Human beta defensin 2 (HBD2) is an endogenous mucosal antimicrobial peptide (AMP) upregulated during infection and inflammation. HBD2 is encoded by the DEFB4 gene, which exhibits extensive copy number variation. Previous studies have demonstrated a relationship between HBD copy number and serum HBD2 protein levels; however, our current understanding of the influence of copy number on mucosal AMP function remains limited. This study explores the relationship between HBD copy number, cervicovaginal HBD2 protein levels and antimicrobial activity in 203 women with risk factors for preterm birth. We provide evidence that suggests HBD copy number modulates cervical antimicrobial immunity. Nature Publishing Group UK 2018-01-24 2018-03 /pmc/articles/PMC5831986/ /pubmed/29367706 http://dx.doi.org/10.1038/s41431-017-0061-7 Text en © European Society of Human Genetics 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
James, Catherine P.
Bajaj-Elliott, Mona
Abujaber, Razan
Forya, Frida
Klein, Nigel
David, Anna L.
Hollox, Edward J.
Peebles, Donald M.
Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy
title Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy
title_full Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy
title_fullStr Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy
title_full_unstemmed Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy
title_short Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy
title_sort human beta defensin (hbd) gene copy number affects hbd2 protein levels: impact on cervical bactericidal immunity in pregnancy
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831986/
https://www.ncbi.nlm.nih.gov/pubmed/29367706
http://dx.doi.org/10.1038/s41431-017-0061-7
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