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Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy

Human beta defensin 2 (HBD2) is an endogenous mucosal antimicrobial peptide (AMP) upregulated during infection and inflammation. HBD2 is encoded by the DEFB4 gene, which exhibits extensive copy number variation. Previous studies have demonstrated a relationship between HBD copy number and serum HBD2...

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Detalles Bibliográficos
Autores principales:	James, Catherine P., Bajaj-Elliott, Mona, Abujaber, Razan, Forya, Frida, Klein, Nigel, David, Anna L., Hollox, Edward J., Peebles, Donald M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831986/ https://www.ncbi.nlm.nih.gov/pubmed/29367706 http://dx.doi.org/10.1038/s41431-017-0061-7

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