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Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study
Salivary gland tumors account for 3–6% of tumors of the head and neck. About 80% of salivary gland tumors occur in parotid glands. Oxidative stress (OS) is implicated in the origin, development, and whole-body effects of various tumors. There are no data on the occurrence of OS in the parotid gland...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832034/ https://www.ncbi.nlm.nih.gov/pubmed/29651432 http://dx.doi.org/10.1155/2018/4340871 |
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author | Sowa, Pawel Misiolek, Maciej Pasinski, Bartlomiej Bartosz, Grzegorz Soszynski, Miroslaw Adamczyk-Sowa, Monika Sadowska-Bartosz, Izabela |
author_facet | Sowa, Pawel Misiolek, Maciej Pasinski, Bartlomiej Bartosz, Grzegorz Soszynski, Miroslaw Adamczyk-Sowa, Monika Sadowska-Bartosz, Izabela |
author_sort | Sowa, Pawel |
collection | PubMed |
description | Salivary gland tumors account for 3–6% of tumors of the head and neck. About 80% of salivary gland tumors occur in parotid glands. Oxidative stress (OS) is implicated in the origin, development, and whole-body effects of various tumors. There are no data on the occurrence of OS in the parotid gland tumors. The aim of this study was to ascertain if whole-body OS accompanies parotid gland tumors, based first of all on oxidative modifications of blood serum proteins and other markers of OS in the serum of the patients. The group studied included 17 patients with pleomorphic adenoma, 9 patients with Warthin's tumor, 8 patients with acinic cell carcinoma, and 24 age-matched controls. We found increased concentration of interleukin 4 in patients with acinic cell carcinoma, decreased plasma thiols, increased AOPP concentration, and decreased FRAP of blood serum in all groups of the patients while protein oxidative modifications assessed fluorimetrically, protein carbonyls, protein nitration, malondialdehyde concentration, and serum ABTS(⁎)-scavenging capacity were unchanged. These data indicate the occurrence of OS in patients with parotid gland tumors and point to various sensitivities of OS markers. |
format | Online Article Text |
id | pubmed-5832034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58320342018-04-12 Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study Sowa, Pawel Misiolek, Maciej Pasinski, Bartlomiej Bartosz, Grzegorz Soszynski, Miroslaw Adamczyk-Sowa, Monika Sadowska-Bartosz, Izabela Biomed Res Int Research Article Salivary gland tumors account for 3–6% of tumors of the head and neck. About 80% of salivary gland tumors occur in parotid glands. Oxidative stress (OS) is implicated in the origin, development, and whole-body effects of various tumors. There are no data on the occurrence of OS in the parotid gland tumors. The aim of this study was to ascertain if whole-body OS accompanies parotid gland tumors, based first of all on oxidative modifications of blood serum proteins and other markers of OS in the serum of the patients. The group studied included 17 patients with pleomorphic adenoma, 9 patients with Warthin's tumor, 8 patients with acinic cell carcinoma, and 24 age-matched controls. We found increased concentration of interleukin 4 in patients with acinic cell carcinoma, decreased plasma thiols, increased AOPP concentration, and decreased FRAP of blood serum in all groups of the patients while protein oxidative modifications assessed fluorimetrically, protein carbonyls, protein nitration, malondialdehyde concentration, and serum ABTS(⁎)-scavenging capacity were unchanged. These data indicate the occurrence of OS in patients with parotid gland tumors and point to various sensitivities of OS markers. Hindawi 2018-01-30 /pmc/articles/PMC5832034/ /pubmed/29651432 http://dx.doi.org/10.1155/2018/4340871 Text en Copyright © 2018 Pawel Sowa et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sowa, Pawel Misiolek, Maciej Pasinski, Bartlomiej Bartosz, Grzegorz Soszynski, Miroslaw Adamczyk-Sowa, Monika Sadowska-Bartosz, Izabela Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study |
title | Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study |
title_full | Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study |
title_fullStr | Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study |
title_full_unstemmed | Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study |
title_short | Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study |
title_sort | oxidative stress markers patients with parotid gland tumors: a pilot study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832034/ https://www.ncbi.nlm.nih.gov/pubmed/29651432 http://dx.doi.org/10.1155/2018/4340871 |
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