MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma

High-mobility group box 1 (HMGB1) is a potential therapeutic target and novel biomarker in a variety of malignant tumors, including hepatocellular carcinoma (HCC). More recently, a number of microRNAs (miRNAs) are identified as a class of regulators for broad control of HMGB1-mediated biological act...

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Detalles Bibliográficos
Autores principales: Yan, Jianing, Ying, Shibo, Cai, Xiujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832039/
https://www.ncbi.nlm.nih.gov/pubmed/29651425
http://dx.doi.org/10.1155/2018/2754941
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author Yan, Jianing
Ying, Shibo
Cai, Xiujun
author_facet Yan, Jianing
Ying, Shibo
Cai, Xiujun
author_sort Yan, Jianing
collection PubMed
description High-mobility group box 1 (HMGB1) is a potential therapeutic target and novel biomarker in a variety of malignant tumors, including hepatocellular carcinoma (HCC). More recently, a number of microRNAs (miRNAs) are identified as a class of regulators for broad control of HMGB1-mediated biological actions in eukaryotic cells. In this review article we will describe representative miRNAs involved in regulating the HMGB1 signaling pathways in HCC cell lines and/or animal models. We also propose the possible mechanisms underlying the miRNA/HMGB1 axis and discuss the future clinical significance of miRNAs targeting HMGB1 molecule for HCC therapy.
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spelling pubmed-58320392018-04-12 MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma Yan, Jianing Ying, Shibo Cai, Xiujun Biomed Res Int Review Article High-mobility group box 1 (HMGB1) is a potential therapeutic target and novel biomarker in a variety of malignant tumors, including hepatocellular carcinoma (HCC). More recently, a number of microRNAs (miRNAs) are identified as a class of regulators for broad control of HMGB1-mediated biological actions in eukaryotic cells. In this review article we will describe representative miRNAs involved in regulating the HMGB1 signaling pathways in HCC cell lines and/or animal models. We also propose the possible mechanisms underlying the miRNA/HMGB1 axis and discuss the future clinical significance of miRNAs targeting HMGB1 molecule for HCC therapy. Hindawi 2018-01-31 /pmc/articles/PMC5832039/ /pubmed/29651425 http://dx.doi.org/10.1155/2018/2754941 Text en Copyright © 2018 Jianing Yan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yan, Jianing
Ying, Shibo
Cai, Xiujun
MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma
title MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma
title_full MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma
title_fullStr MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma
title_full_unstemmed MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma
title_short MicroRNA-Mediated Regulation of HMGB1 in Human Hepatocellular Carcinoma
title_sort microrna-mediated regulation of hmgb1 in human hepatocellular carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832039/
https://www.ncbi.nlm.nih.gov/pubmed/29651425
http://dx.doi.org/10.1155/2018/2754941
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AT caixiujun micrornamediatedregulationofhmgb1inhumanhepatocellularcarcinoma

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