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Downregulation of HIF-2α Reverse the Chemotherapy Resistance of Lung Adenocarcinoma A549 Cells to Cisplatin

BACKGROUND: Cisplatin (DDP)-based systemic chemotherapy has been widely used in the treatment of postoperative or advanced NSCLC patients, however, its effective rate is only 14~40%. HIF-2α can upregulate drug-resistant-related genes expression and lead to chemotherapy resistance in many tumors. How...

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Detalles Bibliográficos
Autores principales:	Gao, Zhao-jia, Yuan, Wei-dong, Yuan, Jun-qiang, Yuan, Kai, Wang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2018
Materias:	Lab/In Vitro Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832106/ https://www.ncbi.nlm.nih.gov/pubmed/29469087 http://dx.doi.org/10.12659/MSM.906107

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