Cargando…

TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton

TGFβ is a potent regulator of several biological functions in many cell types, but its role in the differentiation of human bone marrow-derived skeletal stem cells (hMSCs) is currently poorly understood. In the present study, we demonstrate that a single dose of TGFβ1 prior to induction of osteogeni...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elsafadi, Mona, Manikandan, Muthurangan, Almalki, Sami, Mobarak, Mohammad, Atteya, Muhammad, Iqbal, Zafar, Hashmi, Jamil Amjad, Shaheen, Sameerah, Alajez, Nehad, Alfayez, Musaad, Kassem, Moustapha, Dawud, Raed Abu, Mahmood, Amer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832166/ https://www.ncbi.nlm.nih.gov/pubmed/29535777 http://dx.doi.org/10.1155/2018/6913594

Ejemplares similares

SERPINB2 is a novel TGFβ-responsive lineage fate determinant of human bone marrow stromal cells
por: Elsafadi, Mona, et al.
Publicado: (2017)

Characterization of Cellular and Molecular Heterogeneity of Bone Marrow Stromal Cells
por: Elsafadi, Mona, et al.
Publicado: (2016)

Transgelin is a poor prognostic factor associated with advanced colorectal cancer (CRC) stage promoting tumor growth and migration in a TGFβ-dependent manner
por: Elsafadi, Mona, et al.
Publicado: (2020)

Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation
por: Elsafadi, Mona, et al.
Publicado: (2019)

Author Correction: Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation
por: Elsafadi, Mona, et al.
Publicado: (2019)

Author Correction: Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation
por: Elsafadi, Mona, et al.
Publicado: (2023)

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
por: AlMuraikhi, Nihal, et al.
Publicado: (2019)

Molecular profiling of ALDH1(+) colorectal cancer stem cells reveals preferential activation of MAPK, FAK, and oxidative stress pro-survival signalling pathways
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2018)

Stem cell library screen identified ruxolitinib as regulator of osteoblastic differentiation of human skeletal stem cells
por: AlMuraikhi, Nihal, et al.
Publicado: (2018)

Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity
por: Ali, Dalia, et al.
Publicado: (2018)

Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells
por: AlMuraikhi, Nihal, et al.
Publicado: (2019)

Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2019)

Whole genome mRNA expression profiling revealed multiple deregulated pathways in stromal vascular fraction from erectile dysfunction patients
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2018)

Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organization
por: Elsafadi, M, et al.
Publicado: (2016)

Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2016)

CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors
por: Al-toub, Mashael, et al.
Publicado: (2019)

Concurrent targeting of BMI1 and CDK4/6 abrogates tumor growth in vitro and in vivo
por: Elango, Ramesh, et al.
Publicado: (2019)

Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers
por: Hamam, Rimi, et al.
Publicado: (2017)

Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells
por: Almasoud, Nuha, et al.
Publicado: (2020)

Author Correction: Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells
por: Almasoud, Nuha, et al.
Publicado: (2021)

MicroRNA-3148 acts as molecular switch promoting malignant transformation and adipocytic differentiation of immortalized human bone marrow stromal cells via direct targeting of the SMAD2/TGFβ pathway
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2020)

Multiple intracellular signaling pathways orchestrate adipocytic differentiation of human bone marrow stromal stem cells
por: Ali, Dalia, et al.
Publicado: (2018)

MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM
por: Elango, Ramesh, et al.
Publicado: (2020)

In vitro differentiation of human skin-derived multipotent stromal cells into putative endothelial-like cells
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2012)

microRNA expression profiling on individual breast cancer patients identifies novel panel of circulating microRNA for early detection
por: Hamam, Rimi, et al.
Publicado: (2016)

Cytotoxicity of Different Concentrations of Three Root Canal Sealers on Human Mesenchymal Stem Cells
por: Alsubait, Sara A., et al.
Publicado: (2018)

Inhibition of GSK-3β Enhances Osteoblast Differentiation of Human Mesenchymal Stem Cells through Wnt Signalling Overexpressing Runx2
por: AlMuraikhi, Nihal, et al.
Publicado: (2023)

ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues
por: Periyasami, Govindasami, et al.
Publicado: (2018)

Vitamin C stimulates RNA expression of human gingival fibroblasts proliferation and adhesion in cigarette smokers: An in vitro study
por: Alyami, Ruaa, et al.
Publicado: (2022)

Effects of all-trans retinoic acid on the in vitro maturation of camel (Camelus dromedarius) cumulus-oocyte complexes
por: SAADELDIN, Islam M., et al.
Publicado: (2019)

Enhanced Efficacy of 5-Fluorouracil in Combination with a Dual Histone Deacetylase and Phosphatidylinositide 3-Kinase Inhibitor (CUDC-907) in Colorectal Cancer Cells
por: Hamam, Rimi, et al.
Publicado: (2017)

JAK2 Inhibition by Fedratinib Reduces Osteoblast Differentiation and Mineralisation of Human Mesenchymal Stem Cells
por: AlMuraikhi, Nihal, et al.
Publicado: (2021)

CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells
por: Al-toub, Mashael, et al.
Publicado: (2015)

Thermotolerance and plasticity of camel somatic cells exposed to acute and chronic heat stress
por: Saadeldin, Islam M., et al.
Publicado: (2019)

Pleiotropic effects of cancer cells’ secreted factors on human stromal (mesenchymal) stem cells
por: Al-toub, Mashael, et al.
Publicado: (2013)

Angiogenic Potential of Human Neonatal Foreskin Stromal Cells in the Chick Embryo Chorioallantoic Membrane Model
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2015)

MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1
por: Vishnubalaji, Radhakrishnan, et al.
Publicado: (2016)

Anti-Proliferative Activity of Glucagon-Like Peptide-1 Receptor Agonist on Obesity-Associated Breast Cancer: The Impact on Modulating Adipokines’ Expression in Adipocytes and Cancer Cells
por: Alanteet, Alaa A., et al.
Publicado: (2021)

Molecular characterisation of stromal populations derived from human embryonic stem cells: Similarities to immortalised bone marrow derived stromal stem cells
por: Harkness, Linda, et al.
Publicado: (2015)

Large-Scale Analysis of Gene Expression Data Reveals a Novel Gene Expression Signature Associated with Colorectal Cancer Distant Recurrence
por: Alajez, Nehad M.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_bkoijliqhamm2j76cfbkn9pg5s