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Copolymer-1 enhances cognitive performance in young adult rats
Cognitive impairment is a dysfunction observed as a sequel of various neurodegenerative diseases, as well as a concomitant element in the elderly stages of life. In clinical settings, this malfunction is identified as mild cognitive impairment. Previous studies have suggested that cognitive impairme...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832204/ https://www.ncbi.nlm.nih.gov/pubmed/29494605 http://dx.doi.org/10.1371/journal.pone.0192885 |
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author | Nieto-Vera, Rossana Kahuam-López, Nicolas Meneses, Alfredo Cruz-Martínez, Yolanda Anaya-Jiménez, Rosa María Liy-Salmerón, Gustavo Carvajal, Horacio Guillermo Ponce-López, Maria Teresa Ibarra, Antonio |
author_facet | Nieto-Vera, Rossana Kahuam-López, Nicolas Meneses, Alfredo Cruz-Martínez, Yolanda Anaya-Jiménez, Rosa María Liy-Salmerón, Gustavo Carvajal, Horacio Guillermo Ponce-López, Maria Teresa Ibarra, Antonio |
author_sort | Nieto-Vera, Rossana |
collection | PubMed |
description | Cognitive impairment is a dysfunction observed as a sequel of various neurodegenerative diseases, as well as a concomitant element in the elderly stages of life. In clinical settings, this malfunction is identified as mild cognitive impairment. Previous studies have suggested that cognitive impairment could be the result of a reduction in the expression of brain-derived neurotrophic factor (BDNF) and/or immune dysfunction. Copolymer-1 (Cop-1) is an FDA-approved synthetic peptide capable of inducing the activation of Th2/3 cells, which are able to release BDNF, as well as to migrate and accumulate in the brain. In this study, we evaluated the effect of Cop-1 immunization on improvement of cognition in adult rats. For this purpose, we performed four experiments. We evaluated the effect of Cop-1 immunization on learning/memory using the Morris water maze for spatial memory and autoshaping for associative memory in 3- or 6-month-old rats. BDNF concentrations at the hippocampus were determined by ELISA. Cop-1 immunization induced a significant improvement of spatial memory and associative memory in 6-month-old rats. Likewise, Cop-1 improved spatial memory and associative memory when animals were immunized at 3 months and evaluated at 6 months old. Additionally, Cop-1 induced a significant increase in BDNF levels at the hippocampus. To our knowledge, the present investigation reports the first instance of Cop-1 treatment enhancing cognitive function in normal young adult rats, suggesting that Cop-1 may be a practical therapeutic strategy potentially useful for age- or disease-related cognitive impairment. |
format | Online Article Text |
id | pubmed-5832204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58322042018-03-19 Copolymer-1 enhances cognitive performance in young adult rats Nieto-Vera, Rossana Kahuam-López, Nicolas Meneses, Alfredo Cruz-Martínez, Yolanda Anaya-Jiménez, Rosa María Liy-Salmerón, Gustavo Carvajal, Horacio Guillermo Ponce-López, Maria Teresa Ibarra, Antonio PLoS One Research Article Cognitive impairment is a dysfunction observed as a sequel of various neurodegenerative diseases, as well as a concomitant element in the elderly stages of life. In clinical settings, this malfunction is identified as mild cognitive impairment. Previous studies have suggested that cognitive impairment could be the result of a reduction in the expression of brain-derived neurotrophic factor (BDNF) and/or immune dysfunction. Copolymer-1 (Cop-1) is an FDA-approved synthetic peptide capable of inducing the activation of Th2/3 cells, which are able to release BDNF, as well as to migrate and accumulate in the brain. In this study, we evaluated the effect of Cop-1 immunization on improvement of cognition in adult rats. For this purpose, we performed four experiments. We evaluated the effect of Cop-1 immunization on learning/memory using the Morris water maze for spatial memory and autoshaping for associative memory in 3- or 6-month-old rats. BDNF concentrations at the hippocampus were determined by ELISA. Cop-1 immunization induced a significant improvement of spatial memory and associative memory in 6-month-old rats. Likewise, Cop-1 improved spatial memory and associative memory when animals were immunized at 3 months and evaluated at 6 months old. Additionally, Cop-1 induced a significant increase in BDNF levels at the hippocampus. To our knowledge, the present investigation reports the first instance of Cop-1 treatment enhancing cognitive function in normal young adult rats, suggesting that Cop-1 may be a practical therapeutic strategy potentially useful for age- or disease-related cognitive impairment. Public Library of Science 2018-03-01 /pmc/articles/PMC5832204/ /pubmed/29494605 http://dx.doi.org/10.1371/journal.pone.0192885 Text en © 2018 Nieto-Vera et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Nieto-Vera, Rossana Kahuam-López, Nicolas Meneses, Alfredo Cruz-Martínez, Yolanda Anaya-Jiménez, Rosa María Liy-Salmerón, Gustavo Carvajal, Horacio Guillermo Ponce-López, Maria Teresa Ibarra, Antonio Copolymer-1 enhances cognitive performance in young adult rats |
title | Copolymer-1 enhances cognitive performance in young adult rats |
title_full | Copolymer-1 enhances cognitive performance in young adult rats |
title_fullStr | Copolymer-1 enhances cognitive performance in young adult rats |
title_full_unstemmed | Copolymer-1 enhances cognitive performance in young adult rats |
title_short | Copolymer-1 enhances cognitive performance in young adult rats |
title_sort | copolymer-1 enhances cognitive performance in young adult rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832204/ https://www.ncbi.nlm.nih.gov/pubmed/29494605 http://dx.doi.org/10.1371/journal.pone.0192885 |
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