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The effect of increasing the sulfation level of chondroitin sulfate on anticoagulant specific activity and activation of the kinin system
Oversulfated chondroitin sulfate (OSCS) was identified as a contaminant in certain heparin preparations as the cause of adverse reactions in patients. OSCS was found to possess both plasma anticoagulant activity and the ability to activate prekallikrein to kallikrein. Differentially sulfated chondro...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832253/ https://www.ncbi.nlm.nih.gov/pubmed/29494632 http://dx.doi.org/10.1371/journal.pone.0193482 |