Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients

Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology. We combined metabolomics (GCMS) with kidney gene expression studies to identify...

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Detalles Bibliográficos
Autores principales: Hallan, Stein, Afkarian, Maryam, Zelnick, Leila R., Kestenbaum, Bryan, Sharma, Shoba, Saito, Rintaro, Darshi, Manjula, Barding, Gregory, Raftery, Daniel, Ju, Wenjun, Kretzler, Matthias, Sharma, Kumar, de Boer, Ian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832558/
https://www.ncbi.nlm.nih.gov/pubmed/29128444
http://dx.doi.org/10.1016/j.ebiom.2017.10.027

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