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Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal()
Cancer evolution is a step-wise non-linear process that may start early in life or later in adulthood, and includes pre-malignant (indolent) and malignant phases. Early somatic changes may not be detectable or are found by chance in apparently healthy individuals. The same lesions may be detected in...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832623/ https://www.ncbi.nlm.nih.gov/pubmed/29203377 http://dx.doi.org/10.1016/j.ebiom.2017.11.024 |
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author | Valent, Peter Akin, Cem Arock, Michel Bock, Christoph George, Tracy I. Galli, Stephen J. Gotlib, Jason Haferlach, Torsten Hoermann, Gregor Hermine, Olivier Jäger, Ulrich Kenner, Lukas Kreipe, Hans Majeti, Ravindra Metcalfe, Dean D. Orfao, Alberto Reiter, Andreas Sperr, Wolfgang R. Staber, Philipp B. Sotlar, Karl Schiffer, Charles Superti-Furga, Giulio Horny, Hans-Peter |
author_facet | Valent, Peter Akin, Cem Arock, Michel Bock, Christoph George, Tracy I. Galli, Stephen J. Gotlib, Jason Haferlach, Torsten Hoermann, Gregor Hermine, Olivier Jäger, Ulrich Kenner, Lukas Kreipe, Hans Majeti, Ravindra Metcalfe, Dean D. Orfao, Alberto Reiter, Andreas Sperr, Wolfgang R. Staber, Philipp B. Sotlar, Karl Schiffer, Charles Superti-Furga, Giulio Horny, Hans-Peter |
author_sort | Valent, Peter |
collection | PubMed |
description | Cancer evolution is a step-wise non-linear process that may start early in life or later in adulthood, and includes pre-malignant (indolent) and malignant phases. Early somatic changes may not be detectable or are found by chance in apparently healthy individuals. The same lesions may be detected in pre-malignant clonal conditions. In some patients, these lesions may never become relevant clinically whereas in others, they act together with additional pro-oncogenic hits and thereby contribute to the formation of an overt malignancy. Although some pre-malignant stages of a malignancy have been characterized, no global system to define and to classify these conditions is available. To discuss open issues related to pre-malignant phases of neoplastic disorders, a working conference was organized in Vienna in August 2015. The outcomes of this conference are summarized herein and include a basic proposal for a nomenclature and classification of pre-malignant conditions. This proposal should assist in the communication among patients, physicians and scientists, which is critical as genome-sequencing will soon be offered widely for early cancer-detection. |
format | Online Article Text |
id | pubmed-5832623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-58326232018-03-06 Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal() Valent, Peter Akin, Cem Arock, Michel Bock, Christoph George, Tracy I. Galli, Stephen J. Gotlib, Jason Haferlach, Torsten Hoermann, Gregor Hermine, Olivier Jäger, Ulrich Kenner, Lukas Kreipe, Hans Majeti, Ravindra Metcalfe, Dean D. Orfao, Alberto Reiter, Andreas Sperr, Wolfgang R. Staber, Philipp B. Sotlar, Karl Schiffer, Charles Superti-Furga, Giulio Horny, Hans-Peter EBioMedicine Review Cancer evolution is a step-wise non-linear process that may start early in life or later in adulthood, and includes pre-malignant (indolent) and malignant phases. Early somatic changes may not be detectable or are found by chance in apparently healthy individuals. The same lesions may be detected in pre-malignant clonal conditions. In some patients, these lesions may never become relevant clinically whereas in others, they act together with additional pro-oncogenic hits and thereby contribute to the formation of an overt malignancy. Although some pre-malignant stages of a malignancy have been characterized, no global system to define and to classify these conditions is available. To discuss open issues related to pre-malignant phases of neoplastic disorders, a working conference was organized in Vienna in August 2015. The outcomes of this conference are summarized herein and include a basic proposal for a nomenclature and classification of pre-malignant conditions. This proposal should assist in the communication among patients, physicians and scientists, which is critical as genome-sequencing will soon be offered widely for early cancer-detection. Elsevier 2017-11-26 /pmc/articles/PMC5832623/ /pubmed/29203377 http://dx.doi.org/10.1016/j.ebiom.2017.11.024 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Valent, Peter Akin, Cem Arock, Michel Bock, Christoph George, Tracy I. Galli, Stephen J. Gotlib, Jason Haferlach, Torsten Hoermann, Gregor Hermine, Olivier Jäger, Ulrich Kenner, Lukas Kreipe, Hans Majeti, Ravindra Metcalfe, Dean D. Orfao, Alberto Reiter, Andreas Sperr, Wolfgang R. Staber, Philipp B. Sotlar, Karl Schiffer, Charles Superti-Furga, Giulio Horny, Hans-Peter Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal() |
title | Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal() |
title_full | Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal() |
title_fullStr | Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal() |
title_full_unstemmed | Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal() |
title_short | Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal() |
title_sort | proposed terminology and classification of pre-malignant neoplastic conditions: a consensus proposal() |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832623/ https://www.ncbi.nlm.nih.gov/pubmed/29203377 http://dx.doi.org/10.1016/j.ebiom.2017.11.024 |
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