Cargando…

Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: A systematic review of the real world data

PURPOSE: The aim was to systematically extrapolate the occurrence, risk factors, prognostic characteristics, management and outcome of bone metastases (BM) and skeletal related events (SREs) of breast cancer survivors in the real world clinical setting. METHODS: A systematic literature search of Pub...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Hongwei, Zhu, Wei, Biskup, Ewelina, Yang, Weige, Yang, Ziang, Wang, Hong, Qiu, Xiaochun, Zhang, Chengjiao, Hu, Guangxia, Hu, Guangfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832676/
https://www.ncbi.nlm.nih.gov/pubmed/29511626
http://dx.doi.org/10.1016/j.jbo.2018.01.004
_version_ 1783303347616350208
author Zhang, Hongwei
Zhu, Wei
Biskup, Ewelina
Yang, Weige
Yang, Ziang
Wang, Hong
Qiu, Xiaochun
Zhang, Chengjiao
Hu, Guangxia
Hu, Guangfu
author_facet Zhang, Hongwei
Zhu, Wei
Biskup, Ewelina
Yang, Weige
Yang, Ziang
Wang, Hong
Qiu, Xiaochun
Zhang, Chengjiao
Hu, Guangxia
Hu, Guangfu
author_sort Zhang, Hongwei
collection PubMed
description PURPOSE: The aim was to systematically extrapolate the occurrence, risk factors, prognostic characteristics, management and outcome of bone metastases (BM) and skeletal related events (SREs) of breast cancer survivors in the real world clinical setting. METHODS: A systematic literature search of PubMed, Web of Science, EMBASE OvidSP and EBSCO Academic Search Complete was conducted. Published prospective and retrospective papers investigating BM and SREs in breast cancer patients in non-trial settings were identified and systematically reviewed. RESULTS: Twenty-four studies met the inclusion criteria. Incidences of BM based on new diagnosis, length of BM-free interval (BMFI) and number and sites of BM were detected by 17 of 24 studies. Seven studies included in the review were subjected to analyses of risk factors for BM. Developments of SREs regarding the occurrence ratio of total and specific SREs, SERs-free interval (SREFI) and the first-line therapy for SREs were observed in 16 of 24 studies. Out of 5 studies, we extracted uni- and multivariate analysis of risk factor for SREs and out of 16 studies - predictors for survival in breast cancer patients with BM. CONCLUSIONS: BM and SREs are common problems in non-trial breast cancer populations. Patient demographics, clinical stage, tumor pathological type, molecular receptors status are significantly risk factors for incidence of BM, SREs and the survival. The unique characteristics of BM and SREs in breast cancer patients should be taken into account in future randomized controlled trials, as to optimize individual treatment options and assure a maximally long good quality of life.
format Online
Article
Text
id pubmed-5832676
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-58326762018-03-06 Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: A systematic review of the real world data Zhang, Hongwei Zhu, Wei Biskup, Ewelina Yang, Weige Yang, Ziang Wang, Hong Qiu, Xiaochun Zhang, Chengjiao Hu, Guangxia Hu, Guangfu J Bone Oncol Review Article PURPOSE: The aim was to systematically extrapolate the occurrence, risk factors, prognostic characteristics, management and outcome of bone metastases (BM) and skeletal related events (SREs) of breast cancer survivors in the real world clinical setting. METHODS: A systematic literature search of PubMed, Web of Science, EMBASE OvidSP and EBSCO Academic Search Complete was conducted. Published prospective and retrospective papers investigating BM and SREs in breast cancer patients in non-trial settings were identified and systematically reviewed. RESULTS: Twenty-four studies met the inclusion criteria. Incidences of BM based on new diagnosis, length of BM-free interval (BMFI) and number and sites of BM were detected by 17 of 24 studies. Seven studies included in the review were subjected to analyses of risk factors for BM. Developments of SREs regarding the occurrence ratio of total and specific SREs, SERs-free interval (SREFI) and the first-line therapy for SREs were observed in 16 of 24 studies. Out of 5 studies, we extracted uni- and multivariate analysis of risk factor for SREs and out of 16 studies - predictors for survival in breast cancer patients with BM. CONCLUSIONS: BM and SREs are common problems in non-trial breast cancer populations. Patient demographics, clinical stage, tumor pathological type, molecular receptors status are significantly risk factors for incidence of BM, SREs and the survival. The unique characteristics of BM and SREs in breast cancer patients should be taken into account in future randomized controlled trials, as to optimize individual treatment options and assure a maximally long good quality of life. Elsevier 2018-02-03 /pmc/articles/PMC5832676/ /pubmed/29511626 http://dx.doi.org/10.1016/j.jbo.2018.01.004 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Zhang, Hongwei
Zhu, Wei
Biskup, Ewelina
Yang, Weige
Yang, Ziang
Wang, Hong
Qiu, Xiaochun
Zhang, Chengjiao
Hu, Guangxia
Hu, Guangfu
Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: A systematic review of the real world data
title Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: A systematic review of the real world data
title_full Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: A systematic review of the real world data
title_fullStr Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: A systematic review of the real world data
title_full_unstemmed Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: A systematic review of the real world data
title_short Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: A systematic review of the real world data
title_sort incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (sres) in breast cancer patients: a systematic review of the real world data
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832676/
https://www.ncbi.nlm.nih.gov/pubmed/29511626
http://dx.doi.org/10.1016/j.jbo.2018.01.004
work_keys_str_mv AT zhanghongwei incidenceriskfactorsandprognosticcharacteristicsofbonemetastasesandskeletalrelatedeventssresinbreastcancerpatientsasystematicreviewoftherealworlddata
AT zhuwei incidenceriskfactorsandprognosticcharacteristicsofbonemetastasesandskeletalrelatedeventssresinbreastcancerpatientsasystematicreviewoftherealworlddata
AT biskupewelina incidenceriskfactorsandprognosticcharacteristicsofbonemetastasesandskeletalrelatedeventssresinbreastcancerpatientsasystematicreviewoftherealworlddata
AT yangweige incidenceriskfactorsandprognosticcharacteristicsofbonemetastasesandskeletalrelatedeventssresinbreastcancerpatientsasystematicreviewoftherealworlddata
AT yangziang incidenceriskfactorsandprognosticcharacteristicsofbonemetastasesandskeletalrelatedeventssresinbreastcancerpatientsasystematicreviewoftherealworlddata
AT wanghong incidenceriskfactorsandprognosticcharacteristicsofbonemetastasesandskeletalrelatedeventssresinbreastcancerpatientsasystematicreviewoftherealworlddata
AT qiuxiaochun incidenceriskfactorsandprognosticcharacteristicsofbonemetastasesandskeletalrelatedeventssresinbreastcancerpatientsasystematicreviewoftherealworlddata
AT zhangchengjiao incidenceriskfactorsandprognosticcharacteristicsofbonemetastasesandskeletalrelatedeventssresinbreastcancerpatientsasystematicreviewoftherealworlddata
AT huguangxia incidenceriskfactorsandprognosticcharacteristicsofbonemetastasesandskeletalrelatedeventssresinbreastcancerpatientsasystematicreviewoftherealworlddata
AT huguangfu incidenceriskfactorsandprognosticcharacteristicsofbonemetastasesandskeletalrelatedeventssresinbreastcancerpatientsasystematicreviewoftherealworlddata