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Genetics of biologically based psychological differences

In recent years, substantial effort has gone into disentangling the genetic contribution to individual differences in behaviour (such as personality and temperament traits). Heritability estimates from twin and family studies, and more recently using whole genome approaches, suggest a substantial ge...

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Detalles Bibliográficos
Autores principales: Sallis, Hannah, Davey Smith, George, Munafò, Marcus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832687/
https://www.ncbi.nlm.nih.gov/pubmed/29483347
http://dx.doi.org/10.1098/rstb.2017.0162
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author Sallis, Hannah
Davey Smith, George
Munafò, Marcus R.
author_facet Sallis, Hannah
Davey Smith, George
Munafò, Marcus R.
author_sort Sallis, Hannah
collection PubMed
description In recent years, substantial effort has gone into disentangling the genetic contribution to individual differences in behaviour (such as personality and temperament traits). Heritability estimates from twin and family studies, and more recently using whole genome approaches, suggest a substantial genetic component to these traits. However, efforts to identify the genes that influence these traits have had relatively little success. Here, we review current work investigating the heritability of individual differences in behavioural traits and provide an overview of the results from genome-wide association analyses of these traits to date. In addition, we discuss the implications of these findings for the potential applications of Mendelian randomization. This article is part of the theme issue ‘Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences'.
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spelling pubmed-58326872018-03-05 Genetics of biologically based psychological differences Sallis, Hannah Davey Smith, George Munafò, Marcus R. Philos Trans R Soc Lond B Biol Sci Part II: Genetic and Epigenetic Processes of Temperament Traits In recent years, substantial effort has gone into disentangling the genetic contribution to individual differences in behaviour (such as personality and temperament traits). Heritability estimates from twin and family studies, and more recently using whole genome approaches, suggest a substantial genetic component to these traits. However, efforts to identify the genes that influence these traits have had relatively little success. Here, we review current work investigating the heritability of individual differences in behavioural traits and provide an overview of the results from genome-wide association analyses of these traits to date. In addition, we discuss the implications of these findings for the potential applications of Mendelian randomization. This article is part of the theme issue ‘Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences'. The Royal Society 2018-04-19 2018-02-26 /pmc/articles/PMC5832687/ /pubmed/29483347 http://dx.doi.org/10.1098/rstb.2017.0162 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Part II: Genetic and Epigenetic Processes of Temperament Traits
Sallis, Hannah
Davey Smith, George
Munafò, Marcus R.
Genetics of biologically based psychological differences
title Genetics of biologically based psychological differences
title_full Genetics of biologically based psychological differences
title_fullStr Genetics of biologically based psychological differences
title_full_unstemmed Genetics of biologically based psychological differences
title_short Genetics of biologically based psychological differences
title_sort genetics of biologically based psychological differences
topic Part II: Genetic and Epigenetic Processes of Temperament Traits
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832687/
https://www.ncbi.nlm.nih.gov/pubmed/29483347
http://dx.doi.org/10.1098/rstb.2017.0162
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