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Genetics of biologically based psychological differences
In recent years, substantial effort has gone into disentangling the genetic contribution to individual differences in behaviour (such as personality and temperament traits). Heritability estimates from twin and family studies, and more recently using whole genome approaches, suggest a substantial ge...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832687/ https://www.ncbi.nlm.nih.gov/pubmed/29483347 http://dx.doi.org/10.1098/rstb.2017.0162 |
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author | Sallis, Hannah Davey Smith, George Munafò, Marcus R. |
author_facet | Sallis, Hannah Davey Smith, George Munafò, Marcus R. |
author_sort | Sallis, Hannah |
collection | PubMed |
description | In recent years, substantial effort has gone into disentangling the genetic contribution to individual differences in behaviour (such as personality and temperament traits). Heritability estimates from twin and family studies, and more recently using whole genome approaches, suggest a substantial genetic component to these traits. However, efforts to identify the genes that influence these traits have had relatively little success. Here, we review current work investigating the heritability of individual differences in behavioural traits and provide an overview of the results from genome-wide association analyses of these traits to date. In addition, we discuss the implications of these findings for the potential applications of Mendelian randomization. This article is part of the theme issue ‘Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences'. |
format | Online Article Text |
id | pubmed-5832687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-58326872018-03-05 Genetics of biologically based psychological differences Sallis, Hannah Davey Smith, George Munafò, Marcus R. Philos Trans R Soc Lond B Biol Sci Part II: Genetic and Epigenetic Processes of Temperament Traits In recent years, substantial effort has gone into disentangling the genetic contribution to individual differences in behaviour (such as personality and temperament traits). Heritability estimates from twin and family studies, and more recently using whole genome approaches, suggest a substantial genetic component to these traits. However, efforts to identify the genes that influence these traits have had relatively little success. Here, we review current work investigating the heritability of individual differences in behavioural traits and provide an overview of the results from genome-wide association analyses of these traits to date. In addition, we discuss the implications of these findings for the potential applications of Mendelian randomization. This article is part of the theme issue ‘Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences'. The Royal Society 2018-04-19 2018-02-26 /pmc/articles/PMC5832687/ /pubmed/29483347 http://dx.doi.org/10.1098/rstb.2017.0162 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Part II: Genetic and Epigenetic Processes of Temperament Traits Sallis, Hannah Davey Smith, George Munafò, Marcus R. Genetics of biologically based psychological differences |
title | Genetics of biologically based psychological differences |
title_full | Genetics of biologically based psychological differences |
title_fullStr | Genetics of biologically based psychological differences |
title_full_unstemmed | Genetics of biologically based psychological differences |
title_short | Genetics of biologically based psychological differences |
title_sort | genetics of biologically based psychological differences |
topic | Part II: Genetic and Epigenetic Processes of Temperament Traits |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832687/ https://www.ncbi.nlm.nih.gov/pubmed/29483347 http://dx.doi.org/10.1098/rstb.2017.0162 |
work_keys_str_mv | AT sallishannah geneticsofbiologicallybasedpsychologicaldifferences AT daveysmithgeorge geneticsofbiologicallybasedpsychologicaldifferences AT munafomarcusr geneticsofbiologicallybasedpsychologicaldifferences |