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Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development

Human adult spermatogonial stem cells (hSSCs) must balance self-renewal and differentiation. To understand how this is achieved, we profiled DNA methylation and open chromatin (ATAC-seq) in SSEA4(+) hSSCs, analyzed bulk and single-cell RNA transcriptomes (RNA-seq) in SSEA4(+) hSSCs and differentiati...

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Detalles Bibliográficos
Autores principales:	Guo, Jingtao, Grow, Edward J., Yi, Chongil, Mlcochova, Hana, Maher, Geoffrey J., Lindskog, Cecilia, Murphy, Patrick J., Wike, Candice L., Carrell, Douglas T., Goriely, Anne, Hotaling, James M., Cairns, Bradley R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832720/ https://www.ncbi.nlm.nih.gov/pubmed/28985528 http://dx.doi.org/10.1016/j.stem.2017.09.003

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