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Support for viral persistence in bats from age-specific serology and models of maternal immunity
Spatiotemporally-localised prediction of virus emergence from wildlife requires focused studies on the ecology and immunology of reservoir hosts in their native habitat. Reliable predictions from mathematical models remain difficult in most systems due to a dearth of appropriate empirical data. Our...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832774/ https://www.ncbi.nlm.nih.gov/pubmed/29497106 http://dx.doi.org/10.1038/s41598-018-22236-6 |
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author | Peel, Alison J. Baker, Kate S. Hayman, David T. S. Broder, Christopher C. Cunningham, Andrew A. Fooks, Anthony R. Garnier, Romain Wood, James L. N. Restif, Olivier |
author_facet | Peel, Alison J. Baker, Kate S. Hayman, David T. S. Broder, Christopher C. Cunningham, Andrew A. Fooks, Anthony R. Garnier, Romain Wood, James L. N. Restif, Olivier |
author_sort | Peel, Alison J. |
collection | PubMed |
description | Spatiotemporally-localised prediction of virus emergence from wildlife requires focused studies on the ecology and immunology of reservoir hosts in their native habitat. Reliable predictions from mathematical models remain difficult in most systems due to a dearth of appropriate empirical data. Our goal was to study the circulation and immune dynamics of zoonotic viruses in bat populations and investigate the effects of maternally-derived and acquired immunity on viral persistence. Using rare age-specific serological data from wild-caught Eidolon helvum fruit bats as a case study, we estimated viral transmission parameters for a stochastic infection model. We estimated mean durations of around 6 months for maternally-derived immunity to Lagos bat virus and African henipavirus, whereas acquired immunity was long-lasting (Lagos bat virus: mean 12 years, henipavirus: mean 4 years). In the presence of a seasonal birth pulse, the effect of maternally-derived immunity on virus persistence within modelled bat populations was highly dependent on transmission characteristics. To explain previous reports of viral persistence within small natural and captive E. helvum populations, we hypothesise that some bats must experience prolonged infectious periods or within-host latency. By further elucidating plausible mechanisms of virus persistence in bat populations, we contribute to guidance of future field studies. |
format | Online Article Text |
id | pubmed-5832774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58327742018-03-05 Support for viral persistence in bats from age-specific serology and models of maternal immunity Peel, Alison J. Baker, Kate S. Hayman, David T. S. Broder, Christopher C. Cunningham, Andrew A. Fooks, Anthony R. Garnier, Romain Wood, James L. N. Restif, Olivier Sci Rep Article Spatiotemporally-localised prediction of virus emergence from wildlife requires focused studies on the ecology and immunology of reservoir hosts in their native habitat. Reliable predictions from mathematical models remain difficult in most systems due to a dearth of appropriate empirical data. Our goal was to study the circulation and immune dynamics of zoonotic viruses in bat populations and investigate the effects of maternally-derived and acquired immunity on viral persistence. Using rare age-specific serological data from wild-caught Eidolon helvum fruit bats as a case study, we estimated viral transmission parameters for a stochastic infection model. We estimated mean durations of around 6 months for maternally-derived immunity to Lagos bat virus and African henipavirus, whereas acquired immunity was long-lasting (Lagos bat virus: mean 12 years, henipavirus: mean 4 years). In the presence of a seasonal birth pulse, the effect of maternally-derived immunity on virus persistence within modelled bat populations was highly dependent on transmission characteristics. To explain previous reports of viral persistence within small natural and captive E. helvum populations, we hypothesise that some bats must experience prolonged infectious periods or within-host latency. By further elucidating plausible mechanisms of virus persistence in bat populations, we contribute to guidance of future field studies. Nature Publishing Group UK 2018-03-01 /pmc/articles/PMC5832774/ /pubmed/29497106 http://dx.doi.org/10.1038/s41598-018-22236-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Peel, Alison J. Baker, Kate S. Hayman, David T. S. Broder, Christopher C. Cunningham, Andrew A. Fooks, Anthony R. Garnier, Romain Wood, James L. N. Restif, Olivier Support for viral persistence in bats from age-specific serology and models of maternal immunity |
title | Support for viral persistence in bats from age-specific serology and models of maternal immunity |
title_full | Support for viral persistence in bats from age-specific serology and models of maternal immunity |
title_fullStr | Support for viral persistence in bats from age-specific serology and models of maternal immunity |
title_full_unstemmed | Support for viral persistence in bats from age-specific serology and models of maternal immunity |
title_short | Support for viral persistence in bats from age-specific serology and models of maternal immunity |
title_sort | support for viral persistence in bats from age-specific serology and models of maternal immunity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832774/ https://www.ncbi.nlm.nih.gov/pubmed/29497106 http://dx.doi.org/10.1038/s41598-018-22236-6 |
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