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Support for viral persistence in bats from age-specific serology and models of maternal immunity

Spatiotemporally-localised prediction of virus emergence from wildlife requires focused studies on the ecology and immunology of reservoir hosts in their native habitat. Reliable predictions from mathematical models remain difficult in most systems due to a dearth of appropriate empirical data. Our...

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Autores principales: Peel, Alison J., Baker, Kate S., Hayman, David T. S., Broder, Christopher C., Cunningham, Andrew A., Fooks, Anthony R., Garnier, Romain, Wood, James L. N., Restif, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832774/
https://www.ncbi.nlm.nih.gov/pubmed/29497106
http://dx.doi.org/10.1038/s41598-018-22236-6
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author Peel, Alison J.
Baker, Kate S.
Hayman, David T. S.
Broder, Christopher C.
Cunningham, Andrew A.
Fooks, Anthony R.
Garnier, Romain
Wood, James L. N.
Restif, Olivier
author_facet Peel, Alison J.
Baker, Kate S.
Hayman, David T. S.
Broder, Christopher C.
Cunningham, Andrew A.
Fooks, Anthony R.
Garnier, Romain
Wood, James L. N.
Restif, Olivier
author_sort Peel, Alison J.
collection PubMed
description Spatiotemporally-localised prediction of virus emergence from wildlife requires focused studies on the ecology and immunology of reservoir hosts in their native habitat. Reliable predictions from mathematical models remain difficult in most systems due to a dearth of appropriate empirical data. Our goal was to study the circulation and immune dynamics of zoonotic viruses in bat populations and investigate the effects of maternally-derived and acquired immunity on viral persistence. Using rare age-specific serological data from wild-caught Eidolon helvum fruit bats as a case study, we estimated viral transmission parameters for a stochastic infection model. We estimated mean durations of around 6 months for maternally-derived immunity to Lagos bat virus and African henipavirus, whereas acquired immunity was long-lasting (Lagos bat virus: mean 12 years, henipavirus: mean 4 years). In the presence of a seasonal birth pulse, the effect of maternally-derived immunity on virus persistence within modelled bat populations was highly dependent on transmission characteristics. To explain previous reports of viral persistence within small natural and captive E. helvum populations, we hypothesise that some bats must experience prolonged infectious periods or within-host latency. By further elucidating plausible mechanisms of virus persistence in bat populations, we contribute to guidance of future field studies.
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spelling pubmed-58327742018-03-05 Support for viral persistence in bats from age-specific serology and models of maternal immunity Peel, Alison J. Baker, Kate S. Hayman, David T. S. Broder, Christopher C. Cunningham, Andrew A. Fooks, Anthony R. Garnier, Romain Wood, James L. N. Restif, Olivier Sci Rep Article Spatiotemporally-localised prediction of virus emergence from wildlife requires focused studies on the ecology and immunology of reservoir hosts in their native habitat. Reliable predictions from mathematical models remain difficult in most systems due to a dearth of appropriate empirical data. Our goal was to study the circulation and immune dynamics of zoonotic viruses in bat populations and investigate the effects of maternally-derived and acquired immunity on viral persistence. Using rare age-specific serological data from wild-caught Eidolon helvum fruit bats as a case study, we estimated viral transmission parameters for a stochastic infection model. We estimated mean durations of around 6 months for maternally-derived immunity to Lagos bat virus and African henipavirus, whereas acquired immunity was long-lasting (Lagos bat virus: mean 12 years, henipavirus: mean 4 years). In the presence of a seasonal birth pulse, the effect of maternally-derived immunity on virus persistence within modelled bat populations was highly dependent on transmission characteristics. To explain previous reports of viral persistence within small natural and captive E. helvum populations, we hypothesise that some bats must experience prolonged infectious periods or within-host latency. By further elucidating plausible mechanisms of virus persistence in bat populations, we contribute to guidance of future field studies. Nature Publishing Group UK 2018-03-01 /pmc/articles/PMC5832774/ /pubmed/29497106 http://dx.doi.org/10.1038/s41598-018-22236-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Peel, Alison J.
Baker, Kate S.
Hayman, David T. S.
Broder, Christopher C.
Cunningham, Andrew A.
Fooks, Anthony R.
Garnier, Romain
Wood, James L. N.
Restif, Olivier
Support for viral persistence in bats from age-specific serology and models of maternal immunity
title Support for viral persistence in bats from age-specific serology and models of maternal immunity
title_full Support for viral persistence in bats from age-specific serology and models of maternal immunity
title_fullStr Support for viral persistence in bats from age-specific serology and models of maternal immunity
title_full_unstemmed Support for viral persistence in bats from age-specific serology and models of maternal immunity
title_short Support for viral persistence in bats from age-specific serology and models of maternal immunity
title_sort support for viral persistence in bats from age-specific serology and models of maternal immunity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832774/
https://www.ncbi.nlm.nih.gov/pubmed/29497106
http://dx.doi.org/10.1038/s41598-018-22236-6
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