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Near-infrared laser thermal conjunctivoplasty

Conjunctivochalasis is a common cause of tear dysfunction due to the conjunctiva becoming loose and wrinkly with age. The current solutions to this disease include either surgical excision in the operating room, or thermoreduction of the loose tissue with hot wire in the clinic. We developed a near-...

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Autores principales: Yang, Jianlong, Chandwani, Rahul, Gopinatth, Varun, Boyce, Tim, Pflugfelder, Stephen C., Huang, David, Liu, Gangjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832782/
https://www.ncbi.nlm.nih.gov/pubmed/29497112
http://dx.doi.org/10.1038/s41598-018-22204-0
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author Yang, Jianlong
Chandwani, Rahul
Gopinatth, Varun
Boyce, Tim
Pflugfelder, Stephen C.
Huang, David
Liu, Gangjun
author_facet Yang, Jianlong
Chandwani, Rahul
Gopinatth, Varun
Boyce, Tim
Pflugfelder, Stephen C.
Huang, David
Liu, Gangjun
author_sort Yang, Jianlong
collection PubMed
description Conjunctivochalasis is a common cause of tear dysfunction due to the conjunctiva becoming loose and wrinkly with age. The current solutions to this disease include either surgical excision in the operating room, or thermoreduction of the loose tissue with hot wire in the clinic. We developed a near-infrared laser thermal conjunctivoplasty system. The system utilizes a 1460-nm programmable laser diode system as the light source. At this wavelength, a water absorption peak exists and the blood absorption is minimal, so the heating of redundant conjunctiva is even and there is no bleeding. A miniaturized handheld probe delivers the laser light and reshapes the laser into a 10 × 1 mm(2) line on the working plane. A foot pedal is used to deliver a preset number of calibrated laser pulses. A fold of loose conjunctiva is grasped by a pair of forceps. The NIR laser light is delivered through an optical fiber and a laser line is aimed exactly on the conjunctival fold by a cylindrical lens. Ex vivo experiments using porcine eye was performed to investigate the induced shrinkage of conjunctiva and decide the optimal laser parameters. It was found that up to 45% of conjunctiva shrinkage could be achieved.
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spelling pubmed-58327822018-03-05 Near-infrared laser thermal conjunctivoplasty Yang, Jianlong Chandwani, Rahul Gopinatth, Varun Boyce, Tim Pflugfelder, Stephen C. Huang, David Liu, Gangjun Sci Rep Article Conjunctivochalasis is a common cause of tear dysfunction due to the conjunctiva becoming loose and wrinkly with age. The current solutions to this disease include either surgical excision in the operating room, or thermoreduction of the loose tissue with hot wire in the clinic. We developed a near-infrared laser thermal conjunctivoplasty system. The system utilizes a 1460-nm programmable laser diode system as the light source. At this wavelength, a water absorption peak exists and the blood absorption is minimal, so the heating of redundant conjunctiva is even and there is no bleeding. A miniaturized handheld probe delivers the laser light and reshapes the laser into a 10 × 1 mm(2) line on the working plane. A foot pedal is used to deliver a preset number of calibrated laser pulses. A fold of loose conjunctiva is grasped by a pair of forceps. The NIR laser light is delivered through an optical fiber and a laser line is aimed exactly on the conjunctival fold by a cylindrical lens. Ex vivo experiments using porcine eye was performed to investigate the induced shrinkage of conjunctiva and decide the optimal laser parameters. It was found that up to 45% of conjunctiva shrinkage could be achieved. Nature Publishing Group UK 2018-03-01 /pmc/articles/PMC5832782/ /pubmed/29497112 http://dx.doi.org/10.1038/s41598-018-22204-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yang, Jianlong
Chandwani, Rahul
Gopinatth, Varun
Boyce, Tim
Pflugfelder, Stephen C.
Huang, David
Liu, Gangjun
Near-infrared laser thermal conjunctivoplasty
title Near-infrared laser thermal conjunctivoplasty
title_full Near-infrared laser thermal conjunctivoplasty
title_fullStr Near-infrared laser thermal conjunctivoplasty
title_full_unstemmed Near-infrared laser thermal conjunctivoplasty
title_short Near-infrared laser thermal conjunctivoplasty
title_sort near-infrared laser thermal conjunctivoplasty
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832782/
https://www.ncbi.nlm.nih.gov/pubmed/29497112
http://dx.doi.org/10.1038/s41598-018-22204-0
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