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Genetic study links components of the autonomous nervous system to heart-rate profile during exercise
Heart rate (HR) responds to exercise by increasing during exercise and recovering after exercise. As such, HR is an important predictor of mortality that researchers believe is modulated by the autonomic nervous system. However, the mechanistic basis underlying inter-individual differences has yet t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832790/ https://www.ncbi.nlm.nih.gov/pubmed/29497042 http://dx.doi.org/10.1038/s41467-018-03395-6 |
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author | Verweij, Niek van de Vegte, Yordi J. van der Harst, Pim |
author_facet | Verweij, Niek van de Vegte, Yordi J. van der Harst, Pim |
author_sort | Verweij, Niek |
collection | PubMed |
description | Heart rate (HR) responds to exercise by increasing during exercise and recovering after exercise. As such, HR is an important predictor of mortality that researchers believe is modulated by the autonomic nervous system. However, the mechanistic basis underlying inter-individual differences has yet to be explained. Here, we perform a large-scale genome-wide analysis of HR increase and HR recovery in 58,818 UK Biobank individuals. Twenty-five independent SNPs in 23 loci are identified to be associated (p < 8.3 × 10(−9)) with HR increase or HR recovery. A total of 36 candidate causal genes are prioritized that are enriched for pathways related to neuron biology. No evidence is found of a causal relationship with mortality or cardiovascular diseases. However, a nominal association with parental lifespan requires further study. In conclusion, the findings provide new biological and clinical insight into the mechanistic underpinnings of HR response to exercise. The results also underscore the role of the autonomous nervous system in HR recovery. |
format | Online Article Text |
id | pubmed-5832790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58327902018-03-05 Genetic study links components of the autonomous nervous system to heart-rate profile during exercise Verweij, Niek van de Vegte, Yordi J. van der Harst, Pim Nat Commun Article Heart rate (HR) responds to exercise by increasing during exercise and recovering after exercise. As such, HR is an important predictor of mortality that researchers believe is modulated by the autonomic nervous system. However, the mechanistic basis underlying inter-individual differences has yet to be explained. Here, we perform a large-scale genome-wide analysis of HR increase and HR recovery in 58,818 UK Biobank individuals. Twenty-five independent SNPs in 23 loci are identified to be associated (p < 8.3 × 10(−9)) with HR increase or HR recovery. A total of 36 candidate causal genes are prioritized that are enriched for pathways related to neuron biology. No evidence is found of a causal relationship with mortality or cardiovascular diseases. However, a nominal association with parental lifespan requires further study. In conclusion, the findings provide new biological and clinical insight into the mechanistic underpinnings of HR response to exercise. The results also underscore the role of the autonomous nervous system in HR recovery. Nature Publishing Group UK 2018-03-01 /pmc/articles/PMC5832790/ /pubmed/29497042 http://dx.doi.org/10.1038/s41467-018-03395-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Verweij, Niek van de Vegte, Yordi J. van der Harst, Pim Genetic study links components of the autonomous nervous system to heart-rate profile during exercise |
title | Genetic study links components of the autonomous nervous system to heart-rate profile during exercise |
title_full | Genetic study links components of the autonomous nervous system to heart-rate profile during exercise |
title_fullStr | Genetic study links components of the autonomous nervous system to heart-rate profile during exercise |
title_full_unstemmed | Genetic study links components of the autonomous nervous system to heart-rate profile during exercise |
title_short | Genetic study links components of the autonomous nervous system to heart-rate profile during exercise |
title_sort | genetic study links components of the autonomous nervous system to heart-rate profile during exercise |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832790/ https://www.ncbi.nlm.nih.gov/pubmed/29497042 http://dx.doi.org/10.1038/s41467-018-03395-6 |
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