Elongator and codon bias regulate protein levels in mammalian peripheral neurons

Familial dysautonomia (FD) results from mutation in IKBKAP/ELP1, a gene encoding the scaffolding protein for the Elongator complex. This highly conserved complex is required for the translation of codon-biased genes in lower organisms. Here we investigate whether Elongator serves a similar function...

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Detalles Bibliográficos
Autores principales: Goffena, Joy, Lefcort, Frances, Zhang, Yongqing, Lehrmann, Elin, Chaverra, Marta, Felig, Jehremy, Walters, Joseph, Buksch, Richard, Becker, Kevin G., George, Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832791/
https://www.ncbi.nlm.nih.gov/pubmed/29497044
http://dx.doi.org/10.1038/s41467-018-03221-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832791/
https://www.ncbi.nlm.nih.gov/pubmed/29497044
http://dx.doi.org/10.1038/s41467-018-03221-z

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