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Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice
Activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) has been implicated in diverse kidney diseases, yet its in vivo significance in diabetic nephropathy (DN) is largely unknown. In the present study, we demonstrated a podocyte-specific Rac1-deficient mouse strain and showed that specific...
Autores principales: | Lv, Zhimei, Hu, Mengsi, Fan, Minghua, Li, Xiaobing, Lin, Jiangong, Zhen, Junhui, Wang, Ziyang, Jin, Haijun, Wang, Rong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832796/ https://www.ncbi.nlm.nih.gov/pubmed/29497040 http://dx.doi.org/10.1038/s41419-018-0353-z |
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