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Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review

The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic lateral sclerosis has been intensively studied. However, the origin of these disorders remains uncertain. This review article critically describes the physiology of redox metals that produce oxidative stress, wh...

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Autores principales: Sheykhansari, Sahar, Kozielski, Kristen, Bill, Joachim, Sitti, Metin, Gemmati, Donato, Zamboni, Paolo, Singh, Ajay Vikram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832817/
https://www.ncbi.nlm.nih.gov/pubmed/29497049
http://dx.doi.org/10.1038/s41419-018-0379-2
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author Sheykhansari, Sahar
Kozielski, Kristen
Bill, Joachim
Sitti, Metin
Gemmati, Donato
Zamboni, Paolo
Singh, Ajay Vikram
author_facet Sheykhansari, Sahar
Kozielski, Kristen
Bill, Joachim
Sitti, Metin
Gemmati, Donato
Zamboni, Paolo
Singh, Ajay Vikram
author_sort Sheykhansari, Sahar
collection PubMed
description The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic lateral sclerosis has been intensively studied. However, the origin of these disorders remains uncertain. This review article critically describes the physiology of redox metals that produce oxidative stress, which in turn leads to cascades of immunomodulatory alteration of neurons in multiple sclerosis and amyotrophic lateral sclerosis. Iron and copper overload has been well established in motor neurons of these diseases’ lesions. On the other hand, the role of other metals like cadmium participating indirectly in the redox cascade of neurobiological mechanism is less studied. In the second part of this review, we focus on this less conspicuous correlation between cadmium as an inactive-redox metal and multiple sclerosis and amyotrophic lateral sclerosis, providing novel treatment modalities and approaches as future prospects.
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spelling pubmed-58328172018-03-05 Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review Sheykhansari, Sahar Kozielski, Kristen Bill, Joachim Sitti, Metin Gemmati, Donato Zamboni, Paolo Singh, Ajay Vikram Cell Death Dis Review Article The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic lateral sclerosis has been intensively studied. However, the origin of these disorders remains uncertain. This review article critically describes the physiology of redox metals that produce oxidative stress, which in turn leads to cascades of immunomodulatory alteration of neurons in multiple sclerosis and amyotrophic lateral sclerosis. Iron and copper overload has been well established in motor neurons of these diseases’ lesions. On the other hand, the role of other metals like cadmium participating indirectly in the redox cascade of neurobiological mechanism is less studied. In the second part of this review, we focus on this less conspicuous correlation between cadmium as an inactive-redox metal and multiple sclerosis and amyotrophic lateral sclerosis, providing novel treatment modalities and approaches as future prospects. Nature Publishing Group UK 2018-03-01 /pmc/articles/PMC5832817/ /pubmed/29497049 http://dx.doi.org/10.1038/s41419-018-0379-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Sheykhansari, Sahar
Kozielski, Kristen
Bill, Joachim
Sitti, Metin
Gemmati, Donato
Zamboni, Paolo
Singh, Ajay Vikram
Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review
title Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review
title_full Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review
title_fullStr Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review
title_full_unstemmed Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review
title_short Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review
title_sort redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832817/
https://www.ncbi.nlm.nih.gov/pubmed/29497049
http://dx.doi.org/10.1038/s41419-018-0379-2
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