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Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review
The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic lateral sclerosis has been intensively studied. However, the origin of these disorders remains uncertain. This review article critically describes the physiology of redox metals that produce oxidative stress, wh...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832817/ https://www.ncbi.nlm.nih.gov/pubmed/29497049 http://dx.doi.org/10.1038/s41419-018-0379-2 |
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author | Sheykhansari, Sahar Kozielski, Kristen Bill, Joachim Sitti, Metin Gemmati, Donato Zamboni, Paolo Singh, Ajay Vikram |
author_facet | Sheykhansari, Sahar Kozielski, Kristen Bill, Joachim Sitti, Metin Gemmati, Donato Zamboni, Paolo Singh, Ajay Vikram |
author_sort | Sheykhansari, Sahar |
collection | PubMed |
description | The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic lateral sclerosis has been intensively studied. However, the origin of these disorders remains uncertain. This review article critically describes the physiology of redox metals that produce oxidative stress, which in turn leads to cascades of immunomodulatory alteration of neurons in multiple sclerosis and amyotrophic lateral sclerosis. Iron and copper overload has been well established in motor neurons of these diseases’ lesions. On the other hand, the role of other metals like cadmium participating indirectly in the redox cascade of neurobiological mechanism is less studied. In the second part of this review, we focus on this less conspicuous correlation between cadmium as an inactive-redox metal and multiple sclerosis and amyotrophic lateral sclerosis, providing novel treatment modalities and approaches as future prospects. |
format | Online Article Text |
id | pubmed-5832817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58328172018-03-05 Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review Sheykhansari, Sahar Kozielski, Kristen Bill, Joachim Sitti, Metin Gemmati, Donato Zamboni, Paolo Singh, Ajay Vikram Cell Death Dis Review Article The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic lateral sclerosis has been intensively studied. However, the origin of these disorders remains uncertain. This review article critically describes the physiology of redox metals that produce oxidative stress, which in turn leads to cascades of immunomodulatory alteration of neurons in multiple sclerosis and amyotrophic lateral sclerosis. Iron and copper overload has been well established in motor neurons of these diseases’ lesions. On the other hand, the role of other metals like cadmium participating indirectly in the redox cascade of neurobiological mechanism is less studied. In the second part of this review, we focus on this less conspicuous correlation between cadmium as an inactive-redox metal and multiple sclerosis and amyotrophic lateral sclerosis, providing novel treatment modalities and approaches as future prospects. Nature Publishing Group UK 2018-03-01 /pmc/articles/PMC5832817/ /pubmed/29497049 http://dx.doi.org/10.1038/s41419-018-0379-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Sheykhansari, Sahar Kozielski, Kristen Bill, Joachim Sitti, Metin Gemmati, Donato Zamboni, Paolo Singh, Ajay Vikram Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review |
title | Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review |
title_full | Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review |
title_fullStr | Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review |
title_full_unstemmed | Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review |
title_short | Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review |
title_sort | redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832817/ https://www.ncbi.nlm.nih.gov/pubmed/29497049 http://dx.doi.org/10.1038/s41419-018-0379-2 |
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