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Solution structure and dynamics of anti-CRISPR AcrIIA4, the Cas9 inhibitor

The bacterial CRISPR-Cas system provides adaptive immunity against invading phages. Cas9, an RNA-guided endonuclease, specifically cleaves target DNA substrates and constitutes a well-established platform for genome editing. Recently, anti-CRISPR (Acr) proteins that inhibit Cas9 have been discovered...

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Detalles Bibliográficos
Autores principales:	Kim, Iktae, Jeong, Migyeong, Ka, Donghyun, Han, Mookyoung, Kim, Nak-Kyoon, Bae, Euiyoung, Suh, Jeong-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832863/ https://www.ncbi.nlm.nih.gov/pubmed/29497118 http://dx.doi.org/10.1038/s41598-018-22177-0

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