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Unite to divide: Oligomerization of tubulin and actin homologs regulates initiation of bacterial cell division

To generate two cells from one, bacteria such as Escherichia coli use a complex of membrane-embedded proteins called the divisome that synthesize the division septum. The initial stage of cytokinesis requires a tubulin homolog, FtsZ, which forms polymers that treadmill around the cell circumference....

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Detalles Bibliográficos
Autores principales: Krupka, Marcin, Margolin, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832921/
https://www.ncbi.nlm.nih.gov/pubmed/29560258
http://dx.doi.org/10.12688/f1000research.13504.1
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author Krupka, Marcin
Margolin, William
author_facet Krupka, Marcin
Margolin, William
author_sort Krupka, Marcin
collection PubMed
description To generate two cells from one, bacteria such as Escherichia coli use a complex of membrane-embedded proteins called the divisome that synthesize the division septum. The initial stage of cytokinesis requires a tubulin homolog, FtsZ, which forms polymers that treadmill around the cell circumference. The attachment of these polymers to the cytoplasmic membrane requires an actin homolog, FtsA, which also forms dynamic polymers that directly bind to FtsZ. Recent evidence indicates that FtsA and FtsZ regulate each other’s oligomeric state in E. coli to control the progression of cytokinesis, including the recruitment of septum synthesis proteins. In this review, we focus on recent advances in our understanding of protein-protein association between FtsZ and FtsA in the initial stages of divisome function, mainly in the well-characterized E. coli system.
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spelling pubmed-58329212018-03-19 Unite to divide: Oligomerization of tubulin and actin homologs regulates initiation of bacterial cell division Krupka, Marcin Margolin, William F1000Res Review To generate two cells from one, bacteria such as Escherichia coli use a complex of membrane-embedded proteins called the divisome that synthesize the division septum. The initial stage of cytokinesis requires a tubulin homolog, FtsZ, which forms polymers that treadmill around the cell circumference. The attachment of these polymers to the cytoplasmic membrane requires an actin homolog, FtsA, which also forms dynamic polymers that directly bind to FtsZ. Recent evidence indicates that FtsA and FtsZ regulate each other’s oligomeric state in E. coli to control the progression of cytokinesis, including the recruitment of septum synthesis proteins. In this review, we focus on recent advances in our understanding of protein-protein association between FtsZ and FtsA in the initial stages of divisome function, mainly in the well-characterized E. coli system. F1000 Research Limited 2018-02-28 /pmc/articles/PMC5832921/ /pubmed/29560258 http://dx.doi.org/10.12688/f1000research.13504.1 Text en Copyright: © 2018 Krupka M and Margolin W http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Krupka, Marcin
Margolin, William
Unite to divide: Oligomerization of tubulin and actin homologs regulates initiation of bacterial cell division
title Unite to divide: Oligomerization of tubulin and actin homologs regulates initiation of bacterial cell division
title_full Unite to divide: Oligomerization of tubulin and actin homologs regulates initiation of bacterial cell division
title_fullStr Unite to divide: Oligomerization of tubulin and actin homologs regulates initiation of bacterial cell division
title_full_unstemmed Unite to divide: Oligomerization of tubulin and actin homologs regulates initiation of bacterial cell division
title_short Unite to divide: Oligomerization of tubulin and actin homologs regulates initiation of bacterial cell division
title_sort unite to divide: oligomerization of tubulin and actin homologs regulates initiation of bacterial cell division
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832921/
https://www.ncbi.nlm.nih.gov/pubmed/29560258
http://dx.doi.org/10.12688/f1000research.13504.1
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