Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology

[Image: see text] Understanding the activation and internalization of G protein-coupled receptors (GPCRs) using conditional approaches is paramount to developing new therapeutic strategies. Here, we describe the design, synthesis, and testing of ExONatide, a benzylguanine-linked peptide agonist of t...

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Detalles Bibliográficos
Autores principales: Podewin, Tom, Ast, Julia, Broichhagen, Johannes, Fine, Nicholas H. F., Nasteska, Daniela, Leippe, Philipp, Gailer, Manuel, Buenaventura, Teresa, Kanda, Nisha, Jones, Ben J., M’Kadmi, Celine, Baneres, Jean-Louis, Marie, Jacky, Tomas, Alejandra, Trauner, Dirk, Hoffmann-Röder, Anja, Hodson, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832994/
https://www.ncbi.nlm.nih.gov/pubmed/29532016
http://dx.doi.org/10.1021/acscentsci.7b00237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832994/
https://www.ncbi.nlm.nih.gov/pubmed/29532016
http://dx.doi.org/10.1021/acscentsci.7b00237

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