Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple)

[Image: see text] Expanding the chemical space and simultaneously ensuring synthetic accessibility is of upmost importance, not only for the discovery of effective binders for novel protein classes but, more importantly, for the development of compounds against hard-to-drug proteins. Here, we presen...

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Detalles Bibliográficos
Autores principales: Batiste, Laurent, Unzue, Andrea, Dolbois, Aymeric, Hassler, Fabrice, Wang, Xuan, Deerain, Nicholas, Zhu, Jian, Spiliotopoulos, Dimitrios, Nevado, Cristina, Caflisch, Amedeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833004/
https://www.ncbi.nlm.nih.gov/pubmed/29532017
http://dx.doi.org/10.1021/acscentsci.7b00401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833004/
https://www.ncbi.nlm.nih.gov/pubmed/29532017
http://dx.doi.org/10.1021/acscentsci.7b00401

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