Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer

BACKGROUND: DNA methylation is an important epigenetic modification, associated with gene expression. 5-Methylcytosine and 5-hydroxymethylcytosine are two epigenetic hallmarks that maintain the equilibrium of epigenetic reprogramming. Disequilibrium in genomic methylation leads to carcinogenesis. Th...

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Detalles Bibliográficos
Autores principales: Zhu, Yimin, Lu, Hanlin, Zhang, Dandan, Li, Meiyan, Sun, Xiaohui, Wan, Ledong, Yu, Dan, Tian, Yiping, Jin, Hongchuan, Lin, Aifen, Gao, Fei, Lai, Maode
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833094/
https://www.ncbi.nlm.nih.gov/pubmed/29507648
http://dx.doi.org/10.1186/s13148-018-0458-3

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