Cargando…
Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls
BACKGROUND: To assess the retinal sensitivity in obstructive sleep apnea hypopnea syndrome (OSAHS) patients evaluated with standard automated perimetry (SAP). And to correlate the functional SAP results with structural parameters obtained with optical coherence tomography (OCT). METHODS: This prospe...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833149/ https://www.ncbi.nlm.nih.gov/pubmed/29499674 http://dx.doi.org/10.1186/s12886-018-0728-z |
_version_ | 1783303436298616832 |
---|---|
author | Casas, Paula Ascaso, Francisco J. Vicente, Eugenio Tejero-Garcés, Gloria Adiego, María I. Cristóbal, José A. |
author_facet | Casas, Paula Ascaso, Francisco J. Vicente, Eugenio Tejero-Garcés, Gloria Adiego, María I. Cristóbal, José A. |
author_sort | Casas, Paula |
collection | PubMed |
description | BACKGROUND: To assess the retinal sensitivity in obstructive sleep apnea hypopnea syndrome (OSAHS) patients evaluated with standard automated perimetry (SAP). And to correlate the functional SAP results with structural parameters obtained with optical coherence tomography (OCT). METHODS: This prospective, observational, case-control study consisted of 63 eyes of 63 OSAHS patients (mean age 51.7 ± 12.7 years, best corrected visual acuity ≥20/25, refractive error less than three spherical or two cylindrical diopters, and intraocular pressure < 21 mmHg) who were enrolled and compared with 38 eyes of 38 age-matched controls. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured by Stratus OCT and SAP sensitivities and indices were explored with Humphrey Field Analyzer perimeter. Correlations between functional and structural parameters were calculated, as well as the relationship between ophthalmologic and systemic indices in OSAHS patients. RESULTS: OSAHS patients showed a significant reduction of the sensitivity for superior visual field division (p = 0.034, t-student test). When dividing the OSAHS group in accordance with the severity of the disease, nasal peripapillary RNFL thickness was significantly lower in severe OSAHS than that in controls and mild-moderate cases (p = 0.031 and p = 0.016 respectively, Mann-Whitney U test). There were no differences between groups for SAP parameters. We found no correlation between structural and functional variables. The central visual field sensitivity of the SAP revealed a poor Pearson correlation with the apnea-hipopnea index (0.284, p = 0.024). CONCLUSIONS: Retinal sensitivity show minor differences between healthy subjects and OSAHS. Functional deterioration in OSAHS patients is not easy to demonstrate with visual field examination. |
format | Online Article Text |
id | pubmed-5833149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-58331492018-03-05 Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls Casas, Paula Ascaso, Francisco J. Vicente, Eugenio Tejero-Garcés, Gloria Adiego, María I. Cristóbal, José A. BMC Ophthalmol Research Article BACKGROUND: To assess the retinal sensitivity in obstructive sleep apnea hypopnea syndrome (OSAHS) patients evaluated with standard automated perimetry (SAP). And to correlate the functional SAP results with structural parameters obtained with optical coherence tomography (OCT). METHODS: This prospective, observational, case-control study consisted of 63 eyes of 63 OSAHS patients (mean age 51.7 ± 12.7 years, best corrected visual acuity ≥20/25, refractive error less than three spherical or two cylindrical diopters, and intraocular pressure < 21 mmHg) who were enrolled and compared with 38 eyes of 38 age-matched controls. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured by Stratus OCT and SAP sensitivities and indices were explored with Humphrey Field Analyzer perimeter. Correlations between functional and structural parameters were calculated, as well as the relationship between ophthalmologic and systemic indices in OSAHS patients. RESULTS: OSAHS patients showed a significant reduction of the sensitivity for superior visual field division (p = 0.034, t-student test). When dividing the OSAHS group in accordance with the severity of the disease, nasal peripapillary RNFL thickness was significantly lower in severe OSAHS than that in controls and mild-moderate cases (p = 0.031 and p = 0.016 respectively, Mann-Whitney U test). There were no differences between groups for SAP parameters. We found no correlation between structural and functional variables. The central visual field sensitivity of the SAP revealed a poor Pearson correlation with the apnea-hipopnea index (0.284, p = 0.024). CONCLUSIONS: Retinal sensitivity show minor differences between healthy subjects and OSAHS. Functional deterioration in OSAHS patients is not easy to demonstrate with visual field examination. BioMed Central 2018-03-02 /pmc/articles/PMC5833149/ /pubmed/29499674 http://dx.doi.org/10.1186/s12886-018-0728-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Casas, Paula Ascaso, Francisco J. Vicente, Eugenio Tejero-Garcés, Gloria Adiego, María I. Cristóbal, José A. Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls |
title | Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls |
title_full | Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls |
title_fullStr | Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls |
title_full_unstemmed | Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls |
title_short | Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls |
title_sort | visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833149/ https://www.ncbi.nlm.nih.gov/pubmed/29499674 http://dx.doi.org/10.1186/s12886-018-0728-z |
work_keys_str_mv | AT casaspaula visualfielddefectsandretinalnervefiberimaginginpatientswithobstructivesleepapneasyndromeandinhealthycontrols AT ascasofranciscoj visualfielddefectsandretinalnervefiberimaginginpatientswithobstructivesleepapneasyndromeandinhealthycontrols AT vicenteeugenio visualfielddefectsandretinalnervefiberimaginginpatientswithobstructivesleepapneasyndromeandinhealthycontrols AT tejerogarcesgloria visualfielddefectsandretinalnervefiberimaginginpatientswithobstructivesleepapneasyndromeandinhealthycontrols AT adiegomariai visualfielddefectsandretinalnervefiberimaginginpatientswithobstructivesleepapneasyndromeandinhealthycontrols AT cristobaljosea visualfielddefectsandretinalnervefiberimaginginpatientswithobstructivesleepapneasyndromeandinhealthycontrols |