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Genetic approaches to identify pathological limitations in aortic smooth muscle contraction

Aortic smooth muscle contains limiting amounts of myosin light chain kinase (MLCK) for myosin regulatory light chain (RLC) phosphorylation and contraction that predisposes to thoracic aortic disease in humans containing heterozygous loss-of-function mutations in MYLK. We tested the hypothesis that t...

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Detalles Bibliográficos
Autores principales:	Huang, Jian, Gao, Ning, Wang, Shanzhi, Milewicz, Dianna M., Kamm, Kristine E., Stull, James T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833278/ https://www.ncbi.nlm.nih.gov/pubmed/29494672 http://dx.doi.org/10.1371/journal.pone.0193769

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