Cargando…

The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity

HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation. Recently small nucleotide polymorphisms (SNPs) in the HMG20A gene have been linked to type 2 diabetes mellitus (T2DM) yet neither expression nor function of this T2DM candidate gene in islets is k...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mellado-Gil, Jose M., Fuente-Martín, Esther, Lorenzo, Petra I., Cobo-Vuilleumier, Nadia, López-Noriega, Livia, Martín-Montalvo, Alejandro, Gómez, Irene de Gracia Herrera, Ceballos-Chávez, Maria, Gómez-Jaramillo, Laura, Campos-Caro, Antonio, Romero-Zerbo, Silvana Y., Rodríguez-Comas, Júlia, Servitja, Joan-Marc, Rojo-Martinez, Gemma, Hmadcha, Abdelkrim, Soria, Bernat, Bugliani, Marco, Marchetti, Piero, Bérmudez-Silva, Francisco J., Reyes, Jose C., Aguilar-Diosdado, Manuel, Gauthier, Benoit R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833347/ https://www.ncbi.nlm.nih.gov/pubmed/29449530 http://dx.doi.org/10.1038/s41419-018-0272-z

Ejemplares similares

Dissecting the Brain/Islet Axis in Metabesity
por: Fuente-Martín, Esther, et al.
Publicado: (2019)

The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity
por: Lorenzo, Petra I., et al.
Publicado: (2021)

Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy
por: Hmadcha, Abdelkrim, et al.
Publicado: (2020)

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
por: Cobo-Vuilleumier, Nadia, et al.
Publicado: (2018)

PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet
por: Lorenzo, Petra I., et al.
Publicado: (2015)

Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging
por: López-Noriega, Livia, et al.
Publicado: (2019)

Use of Mesothelial Cells and Biological Matrices for Tissue Engineering of Simple Epithelium Surrogates
por: Lachaud, Christian Claude, et al.
Publicado: (2015)

The immune boundaries for stem cell based therapies: problems and prospective solutions
por: Abdelkrim, Hmadcha, et al.
Publicado: (2009)

Editorial: A Compendium of Recent Research on Stem Cell-Based Therapy for Covid-19
por: Hmadcha, Abdelkrim, et al.
Publicado: (2021)

miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell Maturation
por: López-Beas, Javier, et al.
Publicado: (2018)

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in Aspergillus fumigatus?
por: Gonzalez-Jimenez, Irene, et al.
Publicado: (2021)

Bottlenecks in the Efficient Use of Advanced Therapy Medicinal Products Based on Mesenchymal Stromal Cells
por: Escacena, Natalia, et al.
Publicado: (2015)

Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy
por: Soria, Bernat, et al.
Publicado: (2019)

A Simple High Efficiency Intra-Islet Transduction Protocol Using Lentiviral Vectors
por: Jiménez-Moreno, Carmen María, et al.
Publicado: (2015)

Zn(2+) chelation by serum albumin improves hexameric Zn(2+)-insulin dissociation into monomers after exocytosis
por: Pertusa, José A. G., et al.
Publicado: (2017)

Functional Vascular Smooth Muscle-like Cells Derived from Adult Mouse Uterine Mesothelial Cells
por: Lachaud, Christian Claude, et al.
Publicado: (2013)

Human Omental Mesothelial Cells Impart an Immunomodulatory Landscape Impeding B- and T-Cell Activation
por: Gauthier, Benoit R., et al.
Publicado: (2022)

Resveratrol Ameliorates the Maturation Process of β-Cell-Like Cells Obtained from an Optimized Differentiation Protocol of Human Embryonic Stem Cells
por: Pezzolla, Daniela, et al.
Publicado: (2015)

Adipose Mesenchymal Stromal Cells Isolated From Type 2 Diabetic Patients Display Reduced Fibrinolytic Activity
por: Acosta, Lourdes, et al.
Publicado: (2013)

Transient Downregulation of Nanog and Oct4 Induced by DETA/NO Exposure in Mouse Embryonic Stem Cells Leads to Mesodermal/Endodermal Lineage Differentiation
por: Mora-Castilla, Sergio, et al.
Publicado: (2014)

Umbilical cord mesenchymal stromal cells transplantation delays the onset of hyperglycemia in the RIP-B7.1 mouse model of experimental autoimmune diabetes through multiple immunosuppressive and anti-inflammatory responses
por: Lachaud, C. C., et al.
Publicado: (2023)

Stemness of Human Pluripotent Cells: Hypoxia-Like Response Induced by Low Nitric Oxide
por: Caballano-Infantes, Estefanía, et al.
Publicado: (2021)

PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus
por: Mellado-Gil, José Manuel, et al.
Publicado: (2016)

Islet β-Cell Mass Preservation and Regeneration in Diabetes Mellitus: Four Factors with Potential Therapeutic Interest
por: Mellado-Gil, Jose Manuel, et al.
Publicado: (2012)

Corrigendum to “Islet β-Cell Mass Preservation and Regeneration in Diabetes Mellitus: Four Factors with Potential Therapeutic Interest”
por: Mellado-Gil, Jose Manuel, et al.
Publicado: (2019)

Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice
por: Jurado-Ruiz, Enrique, et al.
Publicado: (2019)

High affinity binding of proteins HMG1 and HMG2 to semicatenated DNA loops
por: Gaillard, Claire, et al.
Publicado: (2000)

Roles of extracellular vesicles associated non-coding RNAs in Diabetes Mellitus
por: Gauthier, Benoit R., et al.
Publicado: (2022)

Molecular Modelling of Islet β-Cell Adaptation to Inflammation in Pregnancy and Gestational Diabetes Mellitus
por: Lorenzo, Petra I., et al.
Publicado: (2019)

Comparative studies on microinjected high-mobility-group chromosomal proteins, HMG1 and HMG2
Publicado: (1981)

Harnessing the Endogenous Plasticity of Pancreatic Islets: A Feasible Regenerative Medicine Therapy for Diabetes?
por: Lorenzo, Petra I., et al.
Publicado: (2021)

The PTGS2/COX2-PGE(2) signaling cascade in inflammation: Pro or anti? A case study with type 1 diabetes mellitus
por: Martín-Vázquez, Eugenia, et al.
Publicado: (2023)

Pyomelanin Formation in Aspergillus fumigatus Requires HmgX and the Transcriptional Activator HmgR but Is Dispensable for Virulence
por: Keller, Sophia, et al.
Publicado: (2011)

HMG Proteins from Molecules to Disease
por: Barreiro-Alonso, Aída, et al.
Publicado: (2022)

HMG-boxes, ribosomopathies and neurodegenerative disease
por: Moss, Tom, et al.
Publicado: (2023)

Chromosomal Proteins HMG-14 and HMG-17 Are Released from Mitotic Chromosomes and Imported into the Nucleus by Active Transport
por: Hock, Robert, et al.
Publicado: (1998)

OR23-3 Differential Effects of Chronic Exposure to Bisphenol-A on Ion Channel Activity and Expression in Mouse Pancreatic Beta-Cells
por: Nadal, Angel, et al.
Publicado: (2019)

Assay for high glucose-mediated islet cell sensitization to apoptosis induced by streptozotocin and cytokines
por: Mellado-Gil, Jose M., et al.
Publicado: (2005)

Methylation-Dependent Gene Silencing Induced by Interleukin 1β via Nitric Oxide Production
por: Hmadcha, Abdelkrim, et al.
Publicado: (1999)

Positive pleiotropic effects of HMG-CoA reductase inhibitor on vitiligo
por: Noël, Martin, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_ebkp2opoj8b9rd0rfptu3avmhq