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Nrf2 antioxidant pathway suppresses Numb-mediated epithelial–mesenchymal transition during pulmonary fibrosis

Epithelial mesenchymal transition (EMT) is a key progression that promotes pulmonary fibrosis (PF). Numb, a phosphotyrosine-binding domain (PTB) protein, is implicated with EMT. Nuclear factor erythroid 2-related factor2 (Nrf2) and its downstream proteins heme oxygenase-1 (HO-1) and NAD(P)H: quinone...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhihui, Qu, Jiao, Zheng, Cheng, Zhang, Panpan, Zhou, Wencheng, Cui, Wenhui, Mo, Xiaoting, Li, Liucheng, Xu, Liang, Gao, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833372/ https://www.ncbi.nlm.nih.gov/pubmed/29362432 http://dx.doi.org/10.1038/s41419-017-0198-x

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