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N6-methyladenosine links RNA metabolism to cancer progression

N6-methyladenosine (m6A) is the most abundant mRNA modification. With the development of antibody-based sequencing technologies and the findings of m6A-related “writers”, “erasers”, and “readers”, the relationships between m6A and mRNA metabolism are emerging. The m6A modification influences almost...

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Autores principales: Dai, Dongjun, Wang, Hanying, Zhu, Liyuan, Jin, Hongchuan, Wang, Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833385/
https://www.ncbi.nlm.nih.gov/pubmed/29374143
http://dx.doi.org/10.1038/s41419-017-0129-x
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author Dai, Dongjun
Wang, Hanying
Zhu, Liyuan
Jin, Hongchuan
Wang, Xian
author_facet Dai, Dongjun
Wang, Hanying
Zhu, Liyuan
Jin, Hongchuan
Wang, Xian
author_sort Dai, Dongjun
collection PubMed
description N6-methyladenosine (m6A) is the most abundant mRNA modification. With the development of antibody-based sequencing technologies and the findings of m6A-related “writers”, “erasers”, and “readers”, the relationships between m6A and mRNA metabolism are emerging. The m6A modification influences almost every step of RNA metabolism that comprises mRNA processing, mRNA exporting from nucleus to cytoplasm, mRNA translation, mRNA decay, and the biogenesis of long-non-coding RNA (lncRNA) and microRNA (miRNA). Recently, more and more studies have found m6A is associated with cancer, contributing to the self-renewal of cancer stem cell, promotion of cancer cell proliferation, and resistance to radiotherapy or chemotherapy. Inhibitors of m6A-related factors have been explored, and some of them were identified to inhibit cancer progression, indicating that m6A could be a target for cancer therapy. In this review, we are trying to summarize the regulation and function of m6A in human carcinogenesis.
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spelling pubmed-58333852018-03-05 N6-methyladenosine links RNA metabolism to cancer progression Dai, Dongjun Wang, Hanying Zhu, Liyuan Jin, Hongchuan Wang, Xian Cell Death Dis Review Article N6-methyladenosine (m6A) is the most abundant mRNA modification. With the development of antibody-based sequencing technologies and the findings of m6A-related “writers”, “erasers”, and “readers”, the relationships between m6A and mRNA metabolism are emerging. The m6A modification influences almost every step of RNA metabolism that comprises mRNA processing, mRNA exporting from nucleus to cytoplasm, mRNA translation, mRNA decay, and the biogenesis of long-non-coding RNA (lncRNA) and microRNA (miRNA). Recently, more and more studies have found m6A is associated with cancer, contributing to the self-renewal of cancer stem cell, promotion of cancer cell proliferation, and resistance to radiotherapy or chemotherapy. Inhibitors of m6A-related factors have been explored, and some of them were identified to inhibit cancer progression, indicating that m6A could be a target for cancer therapy. In this review, we are trying to summarize the regulation and function of m6A in human carcinogenesis. Nature Publishing Group UK 2018-01-26 /pmc/articles/PMC5833385/ /pubmed/29374143 http://dx.doi.org/10.1038/s41419-017-0129-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Dai, Dongjun
Wang, Hanying
Zhu, Liyuan
Jin, Hongchuan
Wang, Xian
N6-methyladenosine links RNA metabolism to cancer progression
title N6-methyladenosine links RNA metabolism to cancer progression
title_full N6-methyladenosine links RNA metabolism to cancer progression
title_fullStr N6-methyladenosine links RNA metabolism to cancer progression
title_full_unstemmed N6-methyladenosine links RNA metabolism to cancer progression
title_short N6-methyladenosine links RNA metabolism to cancer progression
title_sort n6-methyladenosine links rna metabolism to cancer progression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833385/
https://www.ncbi.nlm.nih.gov/pubmed/29374143
http://dx.doi.org/10.1038/s41419-017-0129-x
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