CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis

Mutations of cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis (CF) with a multitude of clinical manifestations. Some CF patients develop clinically significant anemia, suggesting that CFTR may regulate hematopoiesis. Here, we report that cftr mutant zebrafish model ex...

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Detalles Bibliográficos
Autores principales: Sun, Huaqin, Wang, Yan, Zhang, Jieting, Chen, Yan, Liu, Yanyan, Lin, Ziyuan, Liu, Mingfeng, Sheng, Kai, Liao, Huijuan, Tsang, Kam Sze, Zhang, Xiaohu, Jiang, Xiaohua, Xu, Wenming, Mao, Meng, Chan, Hsiao Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833403/
https://www.ncbi.nlm.nih.gov/pubmed/29449653
http://dx.doi.org/10.1038/s41419-018-0311-9

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