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Induction of ER and mitochondrial stress by the alkylphosphocholine erufosine in oral squamous cell carcinoma cells

Endoplasmic reticulum (ER) plays an essential role in cell function and survival. Accumulation of unfolded or misfolded proteins in the lumen of the ER activates the unfolded protein response (UPR), resulting in ER stress and subsequent apoptosis. The alkylphosphocholine erufosine is a known Akt-mTO...

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Detalles Bibliográficos
Autores principales:	Ansari, Shariq S., Sharma, Ashwini K., Soni, Himanshu, Ali, Doaa M., Tews, Björn, König, Rainer, Eibl, Hansjörg, Berger, Martin R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833417/ https://www.ncbi.nlm.nih.gov/pubmed/29463797 http://dx.doi.org/10.1038/s41419-018-0342-2

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