Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension

Calcification is a major risk factor for vascular integrity. This pathological symptom and the underlying mechanisms in hypoxic pulmonary artery hypertension remain elusive. Here we report that pulmonary vascular medial calcification is elevated in pulmonary artery hypertension models as a result of...

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Detalles Bibliográficos
Autores principales: Mao, Min, Zhang, Min, Ge, Anqi, Ge, Xin, Gu, Rui, Zhang, Chen, Fu, Yao, Gao, Jiayin, Wang, Xiaoying, Liu, Yang, Zhu, Daling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833422/
https://www.ncbi.nlm.nih.gov/pubmed/29445095
http://dx.doi.org/10.1038/s41419-018-0315-5

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