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Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes

Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known. Accumulating evidence indicates that structural and functional abnormalities of astrocytes within the optic nerve head (...

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Detalles Bibliográficos
Autores principales: Shim, Myoung Sup, Kim, Keun-Young, Bu, Jung Hyun, Nam, Hye Seung, Jeong, Seung Won, Park, Tae Lim, Ellisman, Mark H., Weinreb, Robert N., Ju, Won-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833440/
https://www.ncbi.nlm.nih.gov/pubmed/29459737
http://dx.doi.org/10.1038/s41419-017-0171-8