PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling

Cancer stem cells (CSCs) are involved in metastasis and resistance development, thus affecting anticancer therapy efficacy. The underlying pathways required for CSC maintenance and survival are not fully understood and only a limited number of treatment strategies to specifically target CSCs have be...

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Detalles Bibliográficos
Autores principales: Klutzny, Saskia, Anurin, Anna, Nicke, Barbara, Regan, Joseph L., Lange, Martin, Schulze, Luise, Parczyk, Karsten, Steigemann, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833477/
https://www.ncbi.nlm.nih.gov/pubmed/29416006
http://dx.doi.org/10.1038/s41419-017-0202-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833477/
https://www.ncbi.nlm.nih.gov/pubmed/29416006
http://dx.doi.org/10.1038/s41419-017-0202-5

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