iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors

Aplastic Anemia (AA) is a bone marrow failure (BMF) disorder, resulting in bone marrow hypocellularity and peripheral pancytopenia. Severe aplastic anemia (SAA) is a subset of AA defined by a more severe phenotype. Although the immunological nature of SAA pathogenesis is widely accepted, there is an...

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Detalles Bibliográficos
Autores principales: Melguizo-Sanchis, Dario, Xu, Yaobo, Taheem, Dheraj, Yu, Min, Tilgner, Katarzyna, Barta, Tomas, Gassner, Katja, Anyfantis, George, Wan, Tengfei, Elango, Ramu, Alharthi, Sameer, El-Harouni, Ashraf A., Przyborski, Stefan, Adam, Soheir, Saretzki, Gabriele, Samarasinghe, Sujith, Armstrong, Lyle, Lako, Majlinda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833558/
https://www.ncbi.nlm.nih.gov/pubmed/29374141
http://dx.doi.org/10.1038/s41419-017-0141-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833558/
https://www.ncbi.nlm.nih.gov/pubmed/29374141
http://dx.doi.org/10.1038/s41419-017-0141-1

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