Cargando…

iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors

Aplastic Anemia (AA) is a bone marrow failure (BMF) disorder, resulting in bone marrow hypocellularity and peripheral pancytopenia. Severe aplastic anemia (SAA) is a subset of AA defined by a more severe phenotype. Although the immunological nature of SAA pathogenesis is widely accepted, there is an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Melguizo-Sanchis, Dario, Xu, Yaobo, Taheem, Dheraj, Yu, Min, Tilgner, Katarzyna, Barta, Tomas, Gassner, Katja, Anyfantis, George, Wan, Tengfei, Elango, Ramu, Alharthi, Sameer, El-Harouni, Ashraf A., Przyborski, Stefan, Adam, Soheir, Saretzki, Gabriele, Samarasinghe, Sujith, Armstrong, Lyle, Lako, Majlinda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833558/ https://www.ncbi.nlm.nih.gov/pubmed/29374141 http://dx.doi.org/10.1038/s41419-017-0141-1

Ejemplares similares

Concise Review: Getting to the Core of Inherited Bone Marrow Failures
por: Adam, Soheir, et al.
Publicado: (2016)

Pluripotent Stem Cell‐Derived Hematopoietic Progenitors Are Unable to Downregulate Key Epithelial‐Mesenchymal Transition‐Associated miRNAs
por: Meader, Ellie, et al.
Publicado: (2017)

The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages
por: Zhu, Lili, et al.
Publicado: (2016)

Derivation and Functional Analysis of Patient-Specific Induced Pluripotent Stem Cells as an In Vitro Model of Chronic Granulomatous Disease
por: Jiang, Yan, et al.
Publicado: (2012)

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age‐Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure
por: Hallam, Dean, et al.
Publicado: (2017)

Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis
por: Yang, Chunbo, et al.
Publicado: (2017)

Hypoxia Inducible Factor-1α in Osteochondral Tissue Engineering
por: Taheem, Dheraj K., et al.
Publicado: (2020)

Editorial: Methods and advances in induced pluripotent stem cells—ophthalmology
por: Armstrong, Lyle, et al.
Publicado: (2023)

Brief Report: Inhibition of miR‐145 Enhances Reprogramming of Human Dermal Fibroblasts to Induced Pluripotent Stem Cells
por: Barta, Tomas, et al.
Publicado: (2015)

Endothelial Differentiation G Protein‐Coupled Receptor 5 Plays an Important Role in Induction and Maintenance of Pluripotency
por: Neganova, Irina, et al.
Publicado: (2019)

JNK/SAPK Signaling Is Essential for Efficient Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells
por: Neganova, Irina, et al.
Publicado: (2016)

Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m.3243A > G mitochondrial DNA mutation
por: Chichagova, Valeria, et al.
Publicado: (2017)

A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A
por: Zhang, Xin, et al.
Publicado: (2009)

Using Zinc Finger Nuclease Technology to Generate CRX‐Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation
por: Collin, Joseph, et al.
Publicado: (2015)

A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs
por: Neganova, Irina, et al.
Publicado: (2017)

Primordial Germ Cells: Current Knowledge and Perspectives
por: Nikolic, Aleksandar, et al.
Publicado: (2016)

Differences in the Activity of Endogenous Bone Morphogenetic Protein Signaling Impact on the Ability of Induced Pluripotent Stem Cells to Differentiate to Corneal Epithelial‐Like Cells
por: Kamarudin, Taty Anna, et al.
Publicado: (2017)

In the eye of the storm: SARS‐CoV‐2 infection and replication at the ocular surface?
por: Armstrong, Lyle, et al.
Publicado: (2021)

Balancing Work and Life: A Conversation with Fiona Watt
por: Lako, Majlinda, et al.
Publicado: (2009)

Retinal organoids provide unique insights into molecular signatures of inherited retinal disease throughout retinogenesis
por: Watson, Avril, et al.
Publicado: (2022)

A Novel Role for miR‐1305 in Regulation of Pluripotency‐Differentiation Balance, Cell Cycle, and Apoptosis in Human Pluripotent Stem Cells
por: Jin, Shibo, et al.
Publicado: (2016)

Room temperature shipment does not affect the biological activity of pluripotent stem cell-derived retinal organoids
por: Georgiou, Maria, et al.
Publicado: (2020)

How to build a human
por: Mellough, Carla B, et al.
Publicado: (2016)

Telomerase in Brain: The New Kid on the Block and Its Role in Neurodegenerative Diseases
por: Saretzki, Gabriele, et al.
Publicado: (2021)

Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line‐ and method‐dependent
por: Chichagova, Valeria, et al.
Publicado: (2019)

Law, Ethics, Religion, and Clinical Translation in the 21(st) Century – A Discussion with Pete Coffey
por: Lako, Majlinda, et al.
Publicado: (2010)

Stem Cells, Inflammation, and Fibrosis
por: Volarevic, Vladislav, et al.
Publicado: (2016)

Direct transcriptomic comparison of xenobiotic metabolism and toxicity pathway induction of airway epithelium models at an air–liquid interface generated from induced pluripotent stem cells and primary bronchial epithelial cells
por: Djidrovski, Ivo, et al.
Publicado: (2022)

Hypoxia impacts human MSC response to substrate stiffness during chondrogenic differentiation
por: Foyt, Daniel A., et al.
Publicado: (2019)

Long-term outcome of a randomized controlled study in patients with newly diagnosed severe aplastic anemia treated with antithymocyte globulin and cyclosporine, with or without granulocyte colony-stimulating factor: a Severe Aplastic Anemia Working Party Trial from the European Group of Blood and Marrow Transplantation
por: Tichelli, André, et al.
Publicado: (2020)

Identification of miRNA–mRNA–TFs regulatory network and crucial pathways involved in asthma through advanced systems biology approaches
por: Shaik, Noor Ahmad, et al.
Publicado: (2022)

Hereditary Hemochromatosis Associated With Idiopathic Refractory Aplastic Anemia in a Five-Year-Old Boy: A Case Report
por: Alharbi, Ibrahim, et al.
Publicado: (2021)

Law, Ethics, Religion, and Clinical Translation in the 21st Century—A Discussion with Andrew Webster
por: Lako, Majlinda, et al.
Publicado: (2010)

Referral Patterns of Patients with Limbal Stem Cell Deficiency to a Specialized Tertiary Center in the United Kingdom
por: Cartes, Cristian, et al.
Publicado: (2021)

Differential Regulation of Human Bone Marrow Mesenchymal Stromal Cell Chondrogenesis by Hypoxia Inducible Factor‐1α Hydroxylase Inhibitors
por: Taheem, Dheraj K., et al.
Publicado: (2018)

APLASTIC ANAEMIA
Publicado: (1979)

Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells
por: Jeong, Minjin, et al.
Publicado: (2018)

Law, Ethics, Religion, and Clinical Translation in the 21st Century—A Discussion with Derek Hei
por: Daher, Susan Rainey, et al.
Publicado: (2010)

Genetic Basis of Inherited Macular Dystrophies and Implications for Stem Cell Therapy
por: Mellough, Carla B, et al.
Publicado: (2009)

Stem Cell-Based Therapy in Transplantation and Immune-Mediated Diseases
por: Volarevic, Vladislav, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_j8uepa7gvjq0vu3lm9th7rpakp