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Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIP(L) in hepatocellular carcinoma

Glycogen synthase kinase-3β (GSK-3β) is a ubiquitously expressed serine/threonine kinase involved in a variety of functions ranging from the control of glycogen metabolism to transcriptional regulation. We recently demonstrated that GSK-3β inhibition triggered ASK1-JNK-dependent apoptosis in human h...

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Detalles Bibliográficos
Autores principales:	Zhang, Na, Liu, Xiaojia, Liu, Lu, Deng, Zhesong, Zeng, Qingxuan, Pang, Weiqiang, Liu, Yang, Song, Danqing, Deng, Hongbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833564/ https://www.ncbi.nlm.nih.gov/pubmed/29445085 http://dx.doi.org/10.1038/s41419-018-0309-3

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